デファクチニブ

デファクチニブ 価格

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デファクチニブ 化学特性,用途語,生産方法

効能

抗悪性腫瘍薬, 接着斑キナーゼ阻害薬

説明

Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that plays a vital role in many oncogenic pathways. Defactinib is a dose-dependent inhibitor of FAK, with maximal inhibition of FAK autophosphorylation in cells achieved at 10 μM. It is less effective against the related kinase PYK2. Defactinib restores the chemosensitivity of taxane-resistant cells to paclitaxel , although it is not cytotoxic alone. Defactinib decreases YB-1 phosphorylation and nuclear accumulation in an Akt-dependent manner. It is orally bioavailable, inhibiting FAK and augmenting paclitaxel action in suppressing the growth and number of ovarian cancer cell tumors in mice.

使用

Defactinib is a selective and orally active FAK inhibitor phase 2. Used in treating cancer patients as it decreases proliferation and increases apoptosis.

デファクチニブ 上流と下流の製品情報

原材料

準備製品

デファクチニブ 生産企業

名前	電話番号	電子メール	国籍	製品カタログ	優位度
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32836	60
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29825	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10522	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
LEAP CHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	24738	58
Coresyn Pharmatech Co., Ltd.	+86-571-86626709 +86-18157142896	cbc@coresyn.com	China	9991	58

1073154-85-4(デファクチニブ)キーワード:

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• 1073154-85-4
• Defactinib
• VS 6063
• VS-6063
• Defactinib(PF-04554878)
• N-methyl-4-(4-((3-(N-methylmethan-3-ylsulfonamido)pyrazin-2-yl)methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)benzamide
• N-Methyl-4-[[4-[[[3-[methyl(methylsulfonyl)amino]-2-pyrazinyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]benzamide
• N-METHYL-4-(4-((3-(N-METHYLMETHYL SULFON
• N-methyl-4-[[4-[[3-[methyl(methylsulfonyl)amino]pyrazin-2-yl]methylamino]-5-(trifluoromethyl)pyrimidin-2-yl]amino]benzamide
• N-methyl-4-((4-(((3-(N-methylmethylsulfonamido)pyrazin-2-yl)methyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzamide Defactinib(PF-04554878)(VS-6063)
• Defactinib free base
• Benzamide, N-methyl-4-[[4-[[[3-[methyl(methylsulfonyl)amino]-2-pyrazinyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-
• CS-1796
• VS-6063; VS6063; VS 6063; PF04554878; PF-04554878; PF 04554878
• PF-04554878 Defactinib
• VS-6063; PF-04554878
• N-methyl-4-(4-((3-(N-methylmethylsulfonamido)pyrazin-2-yl)methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)benzamide
• Defactinib (VS-6063
• VS6063
• デファクチニブ
• N-メチル-4-{[4-({[3-(N-メチルメタンスルホンアミド)ピラジン-2-イル]メチル}アミノ)-5-(トリフルオロメチル)ピリミジン-2-イル]アミノ}ベンズアミド
• 4-[[4-[[3-[メチル(メチルスルホニル)アミノ]ピラジン-2-イルメチル]アミノ]-5-(トリフルオロメチル)ピリミジン-2-イル]アミノ]-N-メチルベンズアミド
• デファシチニブ
• N-メチル-4-[[4-[[3-[メチル(メチルスルホニル)アミノ]ピラジン-2-イル]メチルアミノ]-5-トリフルオロメチルピリミジン-2-イル]アミノ]ベンズアミド