(S,R,S)-AHPC-PEG3-Alkyne

2374122-30-0

CAS番号.: 2374122-30-0

化学名:

别名:

英語名:: (S,R,S)-AHPC-PEG3-Alkyne

英語别名:: (S,R,S)-AHPC-PEG3-Alkyne;(S,R,S)-AHPC-PEG?-Alkyne;(2S,4R)-1-((S)-2-(tert-Butyl)-4-oxo-7,10,13-trioxa-3-azahexadec-15-ynoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide;(2S,4R)-1-[(2S)-3,3-dimethyl-2-(3-{2-[2-(prop-2-yn-1-yloxy)ethoxy]ethoxy}propanamido)butanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide;(2S,4R)-1-((S)-2-(tert-Butyl)-4-oxo-7,10,13-trioxa-3-azahexadec-15-ynoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, Crosslinker–E3 Ligase ligand conjugate, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader, VH032 conjugate

CBNumber:: CB84846305

化学式:: C32H44N4O7S

分子量:: 628.79

MOL File:: 2374122-30-0.mol

MSDS File:: SDS

物理性質

安全性情報

用途語

生産企業 13

(S,R,S)-AHPC-PEG3-Alkyne 物理性質

沸点 :: 881.7±65.0 °C(Predicted)

比重(密度) :: 1.224±0.06 g/cm3(Predicted)

貯蔵温度 :: 2-8°C

酸解離定数(Pka):: 14.07±0.40(Predicted)

安全性情報

(S,R,S)-AHPC-PEG3-Alkyne 価格

メーカー	製品番号	製品説明	CAS番号	包装	価格	更新時間	購入

(S,R,S)-AHPC-PEG3-Alkyne 化学特性,用途語,生産方法

使用

Protein degrader builiding block (S,R,S)-AHPC-PEG4-Alkyne enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with pendant alkyne for click chemistry with an azide on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant alkyne group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

(S,R,S)-AHPC-PEG3-Alkyne 上流と下流の製品情報

原材料

準備製品

(S,R,S)-AHPC-PEG3-Alkyne 生産企業

Global( 13)Suppliers

名前	電話番号	電子メール	国籍	製品カタログ	優位度
Xian confluore Biological Technology Co., Ltd.	+86-15680926068 +86-15680926068	1924344760@confluore.cn	China	2996	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52927	58
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80
ShangHai Biochempartner Co.,Ltd	17754423994 17754423994	2853530910@QQ.com	China	8014	62
Shanghai Chaolan Chemical Technology Center	QQ:65489617 15618227136	info@SuperLan-chem.com	China	9943	58
Xi'an Confluore Biological Technology Co., Ltd.	+86-156-80926068 +86-15680926068	1924344760@qq.com	China	4824	58
Jilin Province Woda Biotechnology Co., Ltd.	13504435624	1927928688@qq.com	China	1382	58
Shanghai Haohong Pharmaceutical Co., Ltd.	4008210725 4008210725	malulu@leyan.com	China	54986	58
Zhengzhou convergence chemical co., LTD	0371-0371-55153829 18003835034	2853979819@qq.com	China	9530	58
Changzhou Bojia Biomedical Technology Co., Ltd.	2122619822	czbjpharma@126.com	China	18488	58

2374122-30-0
(S,R,S)-AHPC-PEG3-Alkyne
(2S,4R)-1-((S)-2-(tert-Butyl)-4-oxo-7,10,13-trioxa-3-azahexadec-15-ynoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, Crosslinker–E3 Ligase ligand conjugate, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader, VH032 conjugate
(2S,4R)-1-((S)-2-(tert-Butyl)-4-oxo-7,10,13-trioxa-3-azahexadec-15-ynoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
(S,R,S)-AHPC-PEG?-Alkyne
(2S,4R)-1-[(2S)-3,3-dimethyl-2-(3-{2-[2-(prop-2-yn-1-yloxy)ethoxy]ethoxy}propanamido)butanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide