A-134974 二塩酸塩 水和物

A-134974 二塩酸塩 水和物 化学構造式
CAS番号.
化学名:
A-134974 二塩酸塩 水和物
别名:
A-134974 二塩酸塩 水和物
英語名:
A-134974 DIHYDROCHLORIDE HYDRATE
英語别名:
A-134974 DIHYDROCHLORIDE HYDRATE;N7-[(1′R,2′S,3′R,4′S)-2′,3′-dihydroxy-4′-aminocyclopentyl]-4-amino-5-iodopyrrolopyrimidine dihydrochloride hydrate;N7-[(1'R,2'S,3'R,4'S)-2',3'-DIHYDROXY-4'-AMINOCYCLOPENTYL]-4-AMINO-5-IODOPYRROLOPYRIMIDINE DIHYDROCHLORIDE HYDRATE
CBNumber:
CB8819039
化学式:
分子量:
0
MOL File:
Mol file

A-134974 二塩酸塩 水和物 物理性質

外見 :
個体
色:
オフホワイトからライトタン

安全性情報

WGK Germany  3

A-134974 二塩酸塩 水和物 価格 もっと(1)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
Sigma-Aldrich Japan A2846 A-134974 二塩酸塩 水和物 ≥98% (HPLC), solid
A-134974 dihydrochloride hydrate ≥98% (HPLC), solid
5mg ¥55400 2024-03-01 購入

A-134974 二塩酸塩 水和物 化学特性,用途語,生産方法

Biochem/physiol Actions

A-134974 is a novel and selective adenosine kinase (AK) inhibitor with IC50 = 60 pM. Systemic A-134974 (i.p.) dose dependently reduced hyperalgesia (ED50= 1 μmol/kg) and at higher doses, reduced locomotor activity (ED50 = 16 μmol/kg). Administration of A-134974 intrathecally (i.t.) was more potent (ED50= 6 nmol) at producing antihyperalgesia than delivering the compound by intracerebralventricular (ED50 = 100 nmol, i.c.v.) or intraplantar (ED50 >300 nmol) routes. In contrast, i.c.v. administration of A-134974 was more effective in reducing locomotor activity than i.t. administration (ED50 values were 1 and >100 nmol, respectively). Increasing the pretreatment time for i.t.-delivered A-134974 caused a greater reduction in locomotor activity (ED50= 10 nmol). This was due to diffusion of A-134974 (i.t.) to supraspinal sites. These data demonstrate that the novel AK inhibitor A-134974 potently reduces thermal hyperalgesia primarily through interactions with spinal sites, whereas its ability to depress locomotor activity is predominantly mediated by supraspinal sites.

A-134974 二塩酸塩 水和物 上流と下流の製品情報

原材料

準備製品


A-134974 二塩酸塩 水和物 生産企業

Global( 2)Suppliers
名前 電話番号 電子メール 国籍 製品カタログ 優位度
Riedel-de Haen AG --
United States 6825 87
SIGMA-RBI --
Switzerland 6913 91

  • N7-[(1'R,2'S,3'R,4'S)-2',3'-DIHYDROXY-4'-AMINOCYCLOPENTYL]-4-AMINO-5-IODOPYRROLOPYRIMIDINE DIHYDROCHLORIDE HYDRATE
  • A-134974 DIHYDROCHLORIDE HYDRATE
  • N7-[(1′R,2′S,3′R,4′S)-2′,3′-dihydroxy-4′-aminocyclopentyl]-4-amino-5-iodopyrrolopyrimidine dihydrochloride hydrate
  • A-134974 二塩酸塩 水和物
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