Glycopyrronium Bromide

 化学構造式
51186-83-5
CAS番号.
51186-83-5
化学名:
别名:
英語名:
Glycopyrronium Bromide
英語别名:
Glonium bromide;GLYCOPYRRONIUM BROMIDE;Glycopyrrolate Impurity 58;GlycopyrroniuM BroMide API;erythro-Glycopyrronium bromide;Glycopyrronium bromide (CHF 5259;Glycopyrronium Bromide / Glycopyrrolate;2-[[2-[(2-aminoacetyl)amino]acetyl]amino]acetic acid (triglycine);(R*,S*)-3-[(Cyclopentylhydroxyphenylacetyl)oxy]-1,1-dimethylpyrrolidinium bromide;Pyrrolidinium, 3-[(cyclopentylhydroxyphenylacetyl)oxy]-1,1-dimethyl-, bromide, (R*,S*)-
CBNumber:
CB91270476
化学式:
C19H28NO3.Br
分子量:
0
MOL File:
51186-83-5.mol
MSDS File:
SDS

Glycopyrronium Bromide 物理性質

融点 :
175℃
溶解性:
水に溶けやすく、エタノール(96%)に溶け、塩化メチレンに非常に溶けにくい。
InChI:
InChI=1/C19H28NO3.BrH/c1-20(2)13-12-17(14-20)23-18(21)19(22,16-10-6-7-11-16)15-8-4-3-5-9-15;/h3-5,8-9,16-17,22H,6-7,10-14H2,1-2H3;1H/q+1;/p-1/t17-,19-;/s3
InChIKey:
VPNYRYCIDCJBOM-SCHKGOGONA-M
SMILES:
[N+]1(C)(C)CC[C@H](OC([C@](C2CCCC2)(O)C2=CC=CC=C2)=O)C1.[Br-] |&1:5,8,r|

安全性情報

HSコード  2933997500

Glycopyrronium Bromide 価格

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入

Glycopyrronium Bromide 化学特性,用途語,生産方法

説明

Glycopyrronium bromide or NVA 237 is a once-daily inhaled antimuscarinic bronchodilator newly approved by the European Commission for use in stable COPD. It is characterized by a quaternary ammonium structure, which reduces its oral bioavailability and, consequently, the systematic effects of any swallowed portion of the drug. Animal studies suggest that there are fewer cardiovascular effects compared to tiotropium because of the higher affinity to M3 versus M2 muscarinic receptors. Human studies showed fast onset of action, sustained bronchodilatation for 24 h, reduced dynamic hyperinflation of the lungs, and improved exercise tolerance. Glycopyrronium bromide in COPD airways clinical trial series (GLOW1–3) are the major clinical trials studying the efficacy and safety of glycopyrronium[1].

化学的特性

White or almost white, crystalline powder.

使用

erythro-Glycopyrronium Bromide is used in preparation of diester containing compounds for treating hyperhidrosis.

適応症

Glycopyrronium bromide is indicated for use as a preoperative antimuscarinic to reduce salivary, tracheobronchial, and pharyngeal secretions; to reduce the volume and free acidity of gastric secretions, and to block cardiac vagal inhibitory reflexes during induction of anaesthesia and intubation when indicated. Glycopyrronium bromide may be used intraoperatively to counteract drug-induced or vagal traction reflexes with the associated arrhythmias. Glycopyrronium bromide protects against the peripheral muscarinic effects (e.g., bradycardia and excessive secretions) of cholinergic agents such as neostigmine and pyridostigmine given to reverse the neuromuscular blockade due to non-depolarising muscle relaxants.

Glycopyrronium Bromide 上流と下流の製品情報

原材料

準備製品


Glycopyrronium Bromide 生産企業

Global( 87)Suppliers
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51186-83-5()キーワード:


  • 51186-83-5
  • erythro-Glycopyrronium bromide
  • Pyrrolidinium, 3-[(cyclopentylhydroxyphenylacetyl)oxy]-1,1-dimethyl-, bromide, (R*,S*)-
  • Pyrrolidinium, 3-[(cyclopentylhydroxyphenylacetyl)oxy]-1,1-dimethyl-, bromide, (R*,S*)-(+-)-
  • (R*,S*)-3-[(Cyclopentylhydroxyphenylacetyl)oxy]-1,1-dimethylpyrrolidinium bromide
  • GlycopyrroniuM BroMide API
  • (3S)-3-{[(2R)-2-Cyclopentyl-2-hydroxy-2-phenylacetyl]oxy}-1,1-dimethylpyrrolidinium bromide
  • Glycopyrronium bromide (CHF 5259
  • Glycopyrronium for peak identification (Y0001309)Q: What is Glycopyrronium for peak identification (Y0001309) Q: What is the CAS Number of Glycopyrronium for peak identification (Y0001309)
  • 2-[[2-[(2-aminoacetyl)amino]acetyl]amino]acetic acid (triglycine)
  • Glycopyrrolate Impurity 58
  • Glycopyrronium Bromide / Glycopyrrolate
  • (3S)-rel-3-[[(2R)-2-cyclopentyl-2-hydroxy-2-phenylacetyl]oxy]-1,1-dimethyl-,Pyrrolidinium bromide (1:1)
  • Glonium bromide
  • GLYCOPYRRONIUM BROMIDE
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