ドーパミン塩酸塩 化学特性,用途語,生産方法
外観
白色～ほとんど白色粉末～結晶
用途
生理、薬離作用研究用。
用途
β1 受容体刺激によるアデニ
ル酸シクラーゼ活性化作用を示します。
効能
強心薬, ドパミン受容体作動薬
商品名
イノバン (協和発酵キリン); イノバン (協和発酵キリン); ドミニン (日本新薬)
説明
Dopamine (hydrochloride) is an endogenous catecholamine neurotransmitter synthesized from the amino acid L-tyrosine that acts as an agonist at dopamine receptors (D
1-5). Dopamine is mainly synthesized in the substantia nigra and ventral tegmental area, and is a precursor in norepinephrine and epinephrine biosynthesis. Dopamine-containing neurons in the brain are involved in reward-motivated behavior, motor control, and hormone release. Dopamine is also synthesized in the adrenal glands where it exerts peripheral paracrine functions including control of vasodilation, sodium excretion, insulin production, gastrointestinal motility, and the activity of lymphocytes. Loss or damage of dopaminergic neurons in the substantia nigra is associated with Parkinson’s disease.
化学的特性
Dopamine hydrochloride is designated chemically as 3,4-dihydroxyphenethylamine hydrochloride, a white crystalline powder freely soluble in water. It can also be dissolved in hot 95% ethanol, methanol, and sodium hydroxide solution. However, it is insoluble in chloroform, ether, and benzene. It has no odor and a slightly bitter taste. Dopamine (also referred to as 3-hydroxytyramine) is a naturally occurring biochemical catecholamine precursor of norepinephrine.
使用
Endogenous catecholamine with α and β-adrenergic activity. Cardiotonic; antihypotensive.
適応症
Dopamine HCl is indicated for the correction of hemodynamic imbalances present in the shock syndrome due to myocardial infarction, trauma, endotoxic septicemia, open-heart surgery, renal failure, and chronic cardiac decompensation as in congestive failure.
主な応用
Dopamine hydrochloride has been used to study dopamine-mediated transient modulation of the physiological responses in whiteleg shrimp, Litopenaeus vannamei.
It has been used to study dopamine-mediated changes in immunity susceptibility to Lactococcus garvieae in the freshwater giant prawn, Macrobrachium rosenbergii.
It has been used to study the molecular link between dopamine-induced oxidative stress and mHtt (mutant Huntingtin) toxicity in relation to the activation of the autophagy pathway in an 'in vitro' model of parkinsonian Huntington's Disease.
製造方法
Dopamine hydrochloride is produced through the ring-opening reaction of piperonyl ethylamine. Piperethylamine and phenol are added to a reaction vessel and cooled down. Hydrochloric acid is slowly added while heating up the mixture to 110°C, and refluxed for 12-44 hours until the reaction reaches completion. The solution is then slightly cooled and water is added, and the mixture is stirred well and allowed to separate into layers. The upper phenolic layer is then removed, and the aqueous layer is extracted with isopropyl acetate. The extracted aqueous layer is then evaporated under reduced pressure (8.0kPa) until dry. Half the amount of ethanol and hydrochloric acid are added to the dry residue and heated to dissolve. The solution is then cooled, crystallized, and filtered. The filter cake is washed with ethanol and dried to obtain the final product, with a yield of 74%.
一般的な説明
Dopamine Hydrochloride is the hydrochloride salt form of dopamine, a monoamine compound with positive inotropic activity. Dopamine is a neurotransmitter which is a naturally occurring catecholamine. Dopamine hydrochloride salt is indicated as a medicine for the treatment of acute congestive and renal failures.
生物活性
Endogenous neurotransmitter that acts as an agonist at dopamine D 1-5 receptors. Synthesized in the substantia nigra and ventral tegmental area, and is a precursor in noradrenalin and adrenalin biosynthesis.
薬物動態学
Dopamine hydrochloride(62-31-7) is a precursor for the synthesis of epinephrine in the body. It has β (mainly β1 receptor) receptor agonism and α receptor agonism, and can also promote the release of norepinephrine. It can enhance myocardial contractility, increase cardiac output, and accelerate the heart rate to a lesser extent (not as obvious as isoproterenol); stimulate the α-receptors of blood vessels in tissues such as skin and muscles, so that blood vessels constrict and blood supply is reduced; it stimulates visceral blood vessels ( The dopamine receptors in the kidney, mesentery, and heart) dilate and increase blood flow. The change of total peripheral resistance is not obvious, but it is beneficial to improve the blood supply of vital organs during shock.
ドーパミン塩酸塩 上流と下流の製品情報
原材料
準備製品