オベチコール酸
|
|
|
- CAS番号.
- 459789-99-2
- 化学名:
- オベチコール酸
- 别名:
- オベチコール酸;オベチコール酸 (JAN);6-エチルケノデオキシコール酸;3α,7α-ジヒドロキシ-6α-エチル-5β-コラン酸;3α,7α-ジヒドロキシ-6α-エチル-5β-コラン-24-酸;オベティコール酸;6-ECDCA;6α-エチル-3α,7α-ジヒドロキシ-5β-コラン-24-酸;6α-エチルケノデオキシコール酸;(4R)-4-[(1R,3aS,3bS,4R,5R,5aS,7R,9aS,9bS,11aR)-5-エチル-4,7-ジヒドロキシ-9a,11a-ジメチル-ヘキサデカヒドロ-1H-シクロペンタ[a]フェナントレン-1-イル]ペンタン酸;(3α,5β,6α,7α)-6-エチル-3,7-ジヒドロキシコラン-24-酸;(3R,6R,7R)-6-エチル-3,7-ジヒドロキシ-5β-コラン-24-酸
- 英語名:
- Obeticholic Acid
- 英語别名:
- 6-Ethylchenodeoxycholic acid;Ocaliva;(R)-4-((3R,5S,6R,7R,8S,9S,10S,13R,14S,17R)-6-ethyl-3,7-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid;9470;1osv;6alph;C15636;6-Ecdca;CS-1441;pha,7aL
- CBNumber:
- CB92484652
- 化学式:
- C26H44O4
- 分子量:
- 420.63
- MOL File:
- 459789-99-2.mol
|
オベチコール酸 物理性質
- 融点 :
- 108-110 °C
- 沸点 :
- 562.9±25.0 °C(Predicted)
- 比重(密度) :
- 1.091
- 貯蔵温度 :
- -20°C
- 溶解性:
- DMSO (最大 35mg/ml) またはエタノール (最大 25mg/ml) に可溶。
- 外見 :
- 白い固体。
- 酸解離定数(Pka):
- 4.76±0.10(Predicted)
- 色:
- 白い
- 安定性：:
- 購入日から2年間安定です。この DMSO またはエタノール溶液は、-20°C で 2 か月間保存できます。
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01TRCE899810 |
6-Ethylchenodeoxycholic Acid |
459789-99-2 |
10mg |
￥38100 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01TRCE899810 |
6-Ethylchenodeoxycholic Acid |
459789-99-2 |
5mg |
￥22300 |
2023-06-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01TRCE899810 |
6-Ethylchenodeoxycholic Acid |
459789-99-2 |
50mg |
￥134100 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01TRCE899810 |
6-Ethylchenodeoxycholic Acid |
459789-99-2 |
100mg |
￥213000 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01TRCE899810 |
6-Ethylchenodeoxycholic Acid |
459789-99-2 |
25mg |
￥71800 |
2023-06-01 |
購入 |
オベチコール酸 化学特性,用途語,生産方法
効能
利胆薬
説明
Obeticholic acid is a potent
and selective farnesoid X receptor agonist that promotes the
flow of bile in the liver. The drug was approved by the
USFDA for the treatment of the rare chronic liver disease
primary biliary cholangitis (PBC) in combination with
ursodeoxycholic acid (UDCA) in adults with inadequate
response to UDCA or as a single agent therapy in adults
unable to tolerate UDCA. Obeticholic acid was discovered at
the Università de Perugia and developed by Intercept
Pharmaceuticals. Obeticholic acid has also been granted orphan
drug designation for the treatment of primary sclerosing
cholangitis and primary biliary cirrhosis and has received
breakthrough therapy designation for the treatment of patients
with nonalcohol steatohepatitis (NASH) with liver fibrosis.
使用
6-Ethylchenodeoxycholic Acid is a derivative of the bile acid Chenodeoxycholic Acid (C291900). 6-Ethylchenodeoxycholic Acid is a potent activator of the farnesoid X nuclear receptor which reduces liver fat and fibrosis in animal models of fatty liver disease.
定義
ChEBI: A dihydroxy-5beta-cholanic acid that is chenodeoxycholic acid carrying an additional ethyl substituent at the 6alpha-position. A semi-synthetic bile acid which acts as a farnesoid X receptor agonist and is used for treatme
t of primary biliary cholangitis.
酵素阻害剤
This semisynthetic bile acid analogue (FW = 420.63 g/mol; CAS 459789- 99-2), also named INT-747, 6α-ethyl-chenodeoxycholate, and (3α,5β,6α, 7α)-6-ethyl-3,7-dihydroxycholan-24-oic acid, is an analogue of the naturally occurring bile acid (FW = 392.57 g/mol; CAS 474-25-9). The latter is synthesized in the liver, where it conjugated to form taurochenodeoxycholate and glycol-chenodeoxycholate, reducing its pKa and increasing retention in the gastrointestinal tract, until reabsorption by the ileum. Chenodeoxycholate is the most active physiological ligand known for the farnesoid X receptor, or FXR (encoded by the NR1H4 gene in humans) that translocates to the nucleus, dimerizes, and binds to hormone response elements. Obeticholic acid reduces bacterial translocation and invasion in cirrhotic rats by restoring intestinal barrier integrity (through increased expression of tight junction proteins) and by inhibiting inflammation. Obeticholate likewise up-regulated expression of the FXR-associated gene small heterodimer partner (SHP).
オベチコール酸 上流と下流の製品情報
原材料
準備製品
オベチコール酸 生産企業
Global( 481)Suppliers
459789-99-2(オベチコール酸)キーワード:
N-[3-(2,1,3-ベンゾチアジアゾール-5-イルアミノ)-2-キノキサリニル]-4-メチルベンゼンスルホンアミド,
セニクリビロック
ビスマス
(R)-4-((3R,5R,8S,9S,10R,13R,14S,17R,E)-6-エチリデン-3-ヒドロキシ-10,13-ジメチル-7-オキソヘキサデカヒドロ-1H-シクロペンタ[A]フェナントレン-17-イル)ペンタン酸
3α-ヒドロキシ-7-オキソ-5β-コラン酸
4-[2-(4-アミノ-1,2,5-オキサジアゾール-3-イル)-1-エチル-7-[[(3S)-3-ピペリジニル]メトキシ]-1H-イミダゾ[4,5-c]ピリジン-4-イル]-2-メチル-3-ブチン-2-オール
ファスジル塩酸塩
SB 431542
LY294002
17-アリルアミノゲルダナマイシン
バンデタニブ
- 459789-99-2
- 6alpha-Ethyl-chenodeoxycholic acid
- 6-Ecdca
- 6alph
- 6-Ethyl-cdca
- C15636
- 6-Ethylchenodeoxycholic acid(Obeticholic Acid)
- Obeticholic Acid
- (3α,5β,6α,7α)-6-ethyl-3,7-dihydroxy-cholan-24-oic acid
- Obetichlolic Acid
- DSP-1747
- 6alpha-ethyl-chenodeoxycholic acid, 6-ECDCA, INT-747
- (4R)-4-[(3R,5S,6R,7R,8S,9S,10S,13R,14S,17R)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid
- CS-1441
- INT-747, 6-ECDCA
- 6-ETHYLCHENODEOXYCHOLIC ACID; OBETICHOLIC ACID; INT 747; INT-747; INT747; 6-ECDCA; OCALIVA.
- 1osv
- 6-ECDCA;INT-747;UNII-0462Z4S4OZ;6-ETHYLCHENODEOXYCHOLIC ACID;6ALPHA-ETHYL-CHENODEOXYCHOLIC ACID;OBETICHOLIC ACID;1OSV;CHC;
- -3,7-dihydroxychoL
- an-24-oic acid
- pha)-6-EthyL
- pha,5beta,6aL
- pha,7aL
- Obeticholic acid(OCA)
- 6-Ethylchenodeoxycholicaci
- Obeticholic Acid USP/EP/BP
- (3alpha,5beta,6alpha,7alpha)-6-Ethyl-3,7-dihydroxycholan-24-...
- US-DMF No.:036292
- 6-Ethylchenodeoxycholic aicd
- 3A, 7A -DIHYDROXY-6A -ETHYL-5B-CHOLAN-24-OIC ACID
- Obeticholic acid 6-ECDCA
- オベチコール酸
- オベチコール酸 (JAN)
- 6-エチルケノデオキシコール酸
- 3α,7α-ジヒドロキシ-6α-エチル-5β-コラン酸
- 3α,7α-ジヒドロキシ-6α-エチル-5β-コラン-24-酸
- オベティコール酸
- 6-ECDCA
- 6α-エチル-3α,7α-ジヒドロキシ-5β-コラン-24-酸
- 6α-エチルケノデオキシコール酸
- (4R)-4-[(1R,3aS,3bS,4R,5R,5aS,7R,9aS,9bS,11aR)-5-エチル-4,7-ジヒドロキシ-9a,11a-ジメチル-ヘキサデカヒドロ-1H-シクロペンタ[a]フェナントレン-1-イル]ペンタン酸
- (3α,5β,6α,7α)-6-エチル-3,7-ジヒドロキシコラン-24-酸
- (3R,6R,7R)-6-エチル-3,7-ジヒドロキシ-5β-コラン-24-酸