YS121 化学特性,用途語,生産方法
説明
Microsomal prostaglandin E
2 synthase-
1 (mPGES-
1), with cyclooxygenase-
2 (COX-
2), synthesizes PGE
2, which is directly involved in signaling during inflammation, fever, and pain. 5-
Lipoxygenase (5-
LO) initiates the synthesis of leukotrienes (LTs), which are pro-
inflammatory mediators. YS-121 is a dual inhibitor of mPGES-
1 (IC
50 = 3.9 μM) and 5-
LO (IC
50 = 4.1 μM). It effectively inhibits PGE
2 and LT synthesis in both cell free and intact cell assays. Moreover, YS-121 (1.5 mg/kg, intraperitoneal) reduced pleural levels of PGE
2 and LTB
4 while blocking exudate formation and leukocyte infiltration in carrageenan-
induced rat pleurisy. YS-121 has minor effects on COX-
1 and COX-
2, inhibiting these enzymes 24.8% and 38%, respectively, at 10 μM.
YS121 上流と下流の製品情報
原材料
準備製品