CASIN
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- CAS番号.
- 425399-05-9
- 化学名:
- 别名:
- 英語名:
- CASIN
- 英語别名:
- CASIN;Casin, >98%;CASIN >=98% (HPLC);Pirl1-related Compound 2;2-(6-phenyl-2,3,4,9-tetrahydro-1H-carbazol-1-ylamino)ethanol;2-[(2,3,4,9-Tetrahydro-6-phenyl-1H-carbazol-1-yl)amino]ethanol;Ethanol, 2-[(2,3,4,9-tetrahydro-6-phenyl-1H-carbazol-1-yl)amino]-;2-((6-Phenyl-2,3,4,9-tetrahydro-1H-carbazol-1-yl)amino)ethan-1-ol;Chemical Intermediate Safe Delivery Manufacturer Supply CAS 9000-71-9 Casein;Ras,multiple myeloma,drug resistance,inhibit,Apoptosis,Inhibitor,CASIN,bortezomib
- CBNumber:
- CB92714663
- 化学式:
- C20H22N2O
- 分子量:
- 306.4
- MOL File:
- 425399-05-9.mol
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CASIN 物理性質
- 沸点 :
- 577.8±50.0 °C(Predicted)
- 比重(密度) :
- 1.23±0.1 g/cm3(Predicted)
- 貯蔵温度 :
- 2-8°C
- 溶解性:
- ≥30.6 mg/mL in DMSO; insoluble in H2O; ≥19.5 mg/mL in EtOH
- 酸解離定数(Pka):
- 14.76±0.10(Predicted)
- 外見 :
- 粉
- 色:
- ホワイトからベリーダークブラウン
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
絵表示(GHS) |
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注意喚起語 |
警告 |
危険有害性情報 |
コード |
危険有害性情報 |
危険有害性クラス |
区分 |
注意喚起語 |
シンボル |
P コード |
H302 |
飲み込むと有害 |
急性毒性、経口 |
4 |
警告 |
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P264, P270, P301+P312, P330, P501 |
H315 |
皮膚刺激 |
皮膚腐食性/刺激性 |
2 |
警告 |
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P264, P280, P302+P352, P321,P332+P313, P362 |
H319 |
強い眼刺激 |
眼に対する重篤な損傷性/眼刺激 性 |
2A |
警告 |
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P264, P280, P305+P351+P338,P337+P313P |
H335 |
呼吸器への刺激のおそれ |
特定標的臓器毒性、単回暴露; 気道刺激性 |
3 |
警告 |
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注意書き |
P261 |
粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。 |
P305+P351+P338 |
眼に入った場合:水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。 |
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メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
富士フイルム和光純薬株式会社(wako)
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W01COBQJ-4722 |
Casin |
425399-05-9 |
100mg |
¥190000 |
2024-03-01 |
購入 |
富士フイルム和光純薬株式会社(wako)
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W01COBQJ-4722 |
Casin |
425399-05-9 |
250mg |
¥315000 |
2024-03-01 |
購入 |
富士フイルム和光純薬株式会社(wako)
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W01TOC5050 |
CASIN |
425399-05-9 |
10mg |
¥80000 |
2024-03-01 |
購入 |
富士フイルム和光純薬株式会社(wako)
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W01COBQJ-4722 |
Casin |
425399-05-9 |
1g |
¥755000 |
2024-03-01 |
購入 |
Sigma-Aldrich Japan
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SML1253 |
≥98% (HPLC)
CASIN ≥98% (HPLC) |
425399-05-9 |
5mg |
¥22400 |
2024-03-01 |
購入 |
CASIN 化学特性,用途語,生産方法
説明
The Rho family of GTPases regulates diverse signal transduction pathways. One member, the cell division control protein 42 homolog (Cdc42), is involved in filopodia function, cell polarity, cell cycling, and other processes. CASIN is an indole-based small molecule that inhibits activation of the Cdc42 GTPase (IC
50 = 2 μM for inhibiting actin assembly in PIP
2-stimulated actin polymerization assays). This compound has been used to explore the role of Cdc42 in the division, survival, and differentiation of hematopoietic stem cells.
使用
CASIN has been used as a cell division control protein 42 homolog (Cdc42) inhibitor:
- to study its effects on the stimulation of extracellular vesicles (EVs) in intestinal epithelial cells
- to study its effects on mice jejunum
- to study its effects on microbial adhesion-triggered endocytosis (MATE) vesicle morphology in segmented filamentous bacteria (SFB)-colonized mice
Biochem/physiol Actions
CASIN is an inhibitor of Cdc42 GTPase, a small GTPase of the Rho-subfamily that plays important roles in cytoskeleton organization, cell cycle progression, signal transduction, and vesicle trafficking. CASIN generated a rejuvenated phenotype of Hematopoietic stem cells (HSCs), reversing the aging-related and polarity phenotype of aged HSCs to that of young HSCs in vivo..
CASIN 上流と下流の製品情報
原材料
準備製品
CASIN 生産企業
Global( 73)Suppliers
- 425399-05-9
- CASIN
- 2-(6-phenyl-2,3,4,9-tetrahydro-1H-carbazol-1-ylamino)ethanol
- 2-[(2,3,4,9-Tetrahydro-6-phenyl-1H-carbazol-1-yl)amino]ethanol
- Casin, >98%
- Pirl1-related Compound 2
- Ethanol, 2-[(2,3,4,9-tetrahydro-6-phenyl-1H-carbazol-1-yl)amino]-
- CASIN >=98% (HPLC)
- Chemical Intermediate Safe Delivery Manufacturer Supply CAS 9000-71-9 Casein
- 2-((6-Phenyl-2,3,4,9-tetrahydro-1H-carbazol-1-yl)amino)ethan-1-ol
- Ras,multiple myeloma,drug resistance,inhibit,Apoptosis,Inhibitor,CASIN,bortezomib