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CFI-400945

化学構造式
1338806-73-7
CAS番号.
1338806-73-7
化学名:
别名:
英語名:
CFI-400945
英語别名:
CFI-400945;ocifisertib;CFI-400945 (CFI400945;CFI-400945 (free base);Ocifisertib（CFI-400945 free base）;CFI400945 free base,CFI 400945 free base;(1R,2S)-2-[3-[(E)-2-[4-[[(2S,6R)-2,6-dimethylmorpholin-4-yl]methyl]phenyl]vinyl]-1H-indazol-6-yl]-5'-methoxy-spiro[cyclopropane-1,3'-indoline]-2'-one;(1R,2S)-2-[3-[(E)-2-[4-[[(2S,6R)-2,6-dimethylmorpholin-4-yl]methyl]phenyl]vinyl]-1H-indazol-6-yl]-5'-methoxy-spiro[cyclopropane-1,3'-indoline]-2'-one;Spiro[cyclopropane-1,3'-[3H]indol]-2'(1'H)-one, 2-[3-[(1E)-2-[4-[[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl]phenyl]ethenyl]-1H-indazol-6-yl]-5'-methoxy-, (1R,2S)-
CBNumber:
CB92716177
化学式:
C33H34N4O3
分子量:
534.65
MOL File:
1338806-73-7.mol

CFI-400945 物理性質

沸点 :
751.5±60.0 °C(Predicted)
比重(密度) :
1.32±0.1 g/cm3(Predicted)
貯蔵温度 :
Store at -20°C
溶解性:
insoluble in H2O; ≥109.8 mg/mL in DMSO; ≥93 mg/mL in EtOH
外見 :
crystalline solid
酸解離定数(Pka):
13.09±0.40(Predicted)
色:
White to yellow

安全性情報

CFI-400945 価格

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入

CFI-400945 化学特性,用途語,生産方法

使用

(1R,?2S)?-2-?[3-?[(1E)?-?2-?[4-?[[(2R,?6S)?-?2,?6-?Dimethyl-?4-?morpholinyl]?methyl]?phenyl]?ethenyl]?-?1H-?indazol-?6-?yl]?-?5''-?methoxy-?spiro[cyclopropane-?1,?3''-?[3H]?indol]?-?2''(1''H)?-?one selectively inhibits polo-like kinase 4 (PLK4), which is a serine/threonine protein kinase that regulates centriole duplication during the cell cycle. PLK4 is a therapeutic target for various cancers.

CFI-400945 上流と下流の製品情報

原材料

準備製品

CFI-400945 生産企業

Global( 61)Suppliers
名前 電話番号 電子メール 国籍 製品カタログ 優位度
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 32760 60
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471
 sales@sarms4muscle.com China 10522 58
InvivoChem 		+1-708-310-1919 +1-13798911105
 sales@invivochem.cn United States 6393 58
TargetMol Chemicals Inc. 		+1-781-999-5354
support@targetmol.com United States 19973 58
Aladdin Scientific 		+1-+1(833)-552-7181
sales@aladdinsci.com United States 57511 58
Suzhou ARTK Medchem Co., Ltd. 		+8618168183658
 sales1@artkmedchem.com China 39009 58
Amadis Chemical Company Limited 		571-89925085
sales@amadischem.com China 131980 58
Shanghai Boyle Chemical Co., Ltd.
sales@boylechem.com China 2923 55
Shanghai Jian Chao Chemical Technology Co., Ltd. 18017383231 18017383231
 lyh_antaeus@163.com China 9352 55
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185
 sales-cpd@caerulumpharma.com China 3453 58

  スペクトルデータ(1HNMR)

CFI-400945(1338806-73-7)1HNMR
  • 1338806-73-7
  • CFI-400945
  • CFI-400945 (free base)
  • CFI-400945 (CFI400945
  • Spiro[cyclopropane-1,3'-[3H]indol]-2'(1'H)-one, 2-[3-[(1E)-2-[4-[[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl]phenyl]ethenyl]-1H-indazol-6-yl]-5'-methoxy-, (1R,2S)-
  • ocifisertib
  • CFI400945 free base,CFI 400945 free base
  • (1R,2S)-2-[3-[(E)-2-[4-[[(2S,6R)-2,6-dimethylmorpholin-4-yl]methyl]phenyl]vinyl]-1H-indazol-6-yl]-5'-methoxy-spiro[cyclopropane-1,3'-indoline]-2'-one
  • (1R,2S)-2-[3-[(E)-2-[4-[[(2S,6R)-2,6-dimethylmorpholin-4-yl]methyl]phenyl]vinyl]-1H-indazol-6-yl]-5'-methoxy-spiro[cyclopropane-1,3'-indoline]-2'-one
  • Ocifisertib（CFI-400945 free base）
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