ブリラシジン 化学特性,用途語,生産方法
効能
抗菌薬
酵素阻害剤
This membrane-lyzing defensin mimetic (FW = 932.98 g/mol; CAS 1224095-98-0; IUPAC: N,N’-bis[3-{[5-(carbamimidoylamino)pentanoyl] amino}-2-[(3R)-pyrrolidin-3-yloxy]-5-(trifluoromethyl)phenyl]pyrimidine- 4,6-dicarboxamide)) is bactericidal (not simply bacteriostatic like most antibiotic) toward a broad spectrum of bacteria, but not mammalian cells. Brilacidin kills many Gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA) and Enterococcus faecium as well as Gramnegative bacteria, including Eschericia coli and Klebsiella pneumonia (NDM). This action of this drug commend it for use in controlling Acute Bacterial Skin and Skin Structure Infections (ABSSSI). A five-day treatment course is usually effective in the treatment of many infections, and, given its direct membrane-disrupting action, bacteria are highly unlikely to acquire resistance to brilacidin.
ブリラシジン 上流と下流の製品情報
原材料
1-?Pyrrolidinecarboxyli?c acid, 3,?3'-?[4,?6-?pyrimidinediylbis[ca?rbonylimino[6-?[[5-?[[bis[[(1,?1-?dimethylethoxy)?carbonyl]?amino]?methylene]?amino]?-?1-?oxopentyl]?amino]?-?4-?(trifluoromethyl)?-?2,?1-?phenylene]?oxy]?]?bis-?, 1,?1'-?bis(1,?1-?dimethylethyl) ester, (3R,?3'R)?-
準備製品