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ABT-639

化学構造式
1235560-28-7
CAS番号.
1235560-28-7
化学名:
别名:
英語名:
ABT-639
英語别名:
ABT-639;ABT-693;CS-2286;ABT-639 (ABT639;ABT-639, CID 46851313;Calcium Channel,Ca channels,Ca2+ channels,inhibit,Inhibitor,ABT639,ABT-639;(R)-4-chloro-2-fluoro-N-(2-fluorophenyl)-5-(octahydropyrrolo[1,2-a]pyrazine-2-carbonyl)benzenesulfonamide;4-CHLORO-2-FLURO-N-(2-FLUOROPHENYL)-5-[(8AR)-HEXAHYDROPYRROLO[1,2-A]PYRAZIN-2(1H)-YLCARBONYL]BENZENESULFONAMIDE;4-Chloro-2-fluoro-N-(2-fluorophenyl)-5-[[(8aR)-hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]carbonyl]benzenesulfonamide;Benzenesulfonamide, 4-chloro-2-fluoro-N-(2-fluorophenyl)-5-[[(8aR)-hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]carbonyl]-
CBNumber:
CB93121075
化学式:
C20H20ClF2N3O3S
分子量:
455.91
MOL File:
1235560-28-7.mol

ABT-639 物理性質

沸点 :
612.2±65.0 °C(Predicted)
比重(密度) :
1.51±0.1 g/cm3(Predicted)
貯蔵温度 :
Store at -20°C
溶解性:
DMSO:9.71(Max Conc. mg/mL);21.3(Max Conc. mM)
DMF:14.0(Max Conc. mg/mL);30.71(Max Conc. mM)
DMF:PBS (pH 7.2) (1:20):0.04(Max Conc. mg/mL);0.09(Max Conc. mM)
Ethanol:0.5(Max Conc. mg/mL);1.1(Max Conc. mM)
外見 :
A solid
酸解離定数(Pka):
6.80±0.10(Predicted)
色:
White to off-white

安全性情報

ABT-639 価格

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入

ABT-639 化学特性,用途語,生産方法

説明

ABT-639 is a selective T-type calcium channel blocker with efficacy in a wide range of preclinical models of nociceptive and neuropathic pain.ABT-639 produces robust antinociceptive activity in experimental pain models at doses that do not significantly alter psychomotor or hemodynamic function in the rat.

参考文献

Zhang, Q., et al. "Optimization of ADME Properties for Sulfonamides Leading to the Discovery of a T-Type Calcium Channel Blocker, ABT-639."Acs Medicinal Chemistry Letters6.6(2015):150429091057009.
Serra, J, et al. "Effects of a T-type calcium channel blocker, ABT-639, on spontaneous activity in C-nociceptors in patients with painful diabetic neuropathy: a randomized controlled trial. " Pain 156.11(2015):2175.
http://www.medkoo.com/products/6989

ABT-639 上流と下流の製品情報

原材料

準備製品

ABT-639 生産企業

Global( 66)Suppliers
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ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
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Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525
 masar@topule.com China 8467 58

  スペクトルデータ(1HNMR)

ABT-639(1235560-28-7)1HNMR

1235560-28-7()キーワード:

7-[6-(1-ヒドロキシ-1-メチルエチル)-3-ピリジニル]-1-(4β-メトキシシクロヘキサン-1α-イル)-3,4-ジヒドロピラジノ[2,3-b]ピラジン-2(1H)-オン
  • 1235560-28-7
  • ABT-639
  • 4-Chloro-2-fluoro-N-(2-fluorophenyl)-5-[[(8aR)-hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]carbonyl]benzenesulfonamide
  • 4-CHLORO-2-FLURO-N-(2-FLUOROPHENYL)-5-[(8AR)-HEXAHYDROPYRROLO[1,2-A]PYRAZIN-2(1H)-YLCARBONYL]BENZENESULFONAMIDE
  • ABT-639, CID 46851313
  • (R)-4-chloro-2-fluoro-N-(2-fluorophenyl)-5-(octahydropyrrolo[1,2-a]pyrazine-2-carbonyl)benzenesulfonamide
  • ABT-639 (ABT639
  • CS-2286
  • ABT-693
  • Benzenesulfonamide, 4-chloro-2-fluoro-N-(2-fluorophenyl)-5-[[(8aR)-hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]carbonyl]-
  • Calcium Channel,Ca channels,Ca2+ channels,inhibit,Inhibitor,ABT639,ABT-639
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