GUAYEWUANINE B 化学特性,用途語,生産方法
説明
A aconite alkaloid present in Aconitum fischeri Reich, A. sachalinense, Fr.
Schmidt (Saghalien) and A. subcuneaturn, Nakai, this base is amorphous but
yields crystalline salts, e.g. the perchlorate, m.p. 230-2°C (dec.); aurich10ride,
m.p. 208-9°C (dec.) and a perbromide, m.p. 181-2°C (dec.). Boiling dilute
H2S04 causes hydrolysis with the production of acetic acid and jesanisaconine
(p-anisoylaconine) forming a crystalline hydrochloride, m.p. 209- 21 O°C (dec.).Alkaline hydrolysis gives acetic and p-anisic acids and aconine. Pyrolysis furnishes
pyrojesaconitine, obtained as the crystalline perchlorate, m.p. 171-2°C; [α]
13D -
27.4° (MeOH). Oxidation with KMn04 yields acetaldehyde, indicative of an
ethylimino group. The structure of the alkaloid has been determined by con_x0002_tinuous monitoring of the pyrolysis and an examination of the products
produced.
Jesaconitine is, like all of the aconitines, highly toxic producing raspiratory
paralysis and a direct toxic action on the heart, the latter often terminating in
ventricular fibrillation.
天然物の起源
A complex aconitine alkaloid, yunaconitine has been isolated from Aconitum hemsJeyanum.
参考文献
Makoshi., Arch. Pharm., 247,243 (1909)
Majima, Suginome, Morio., Ber., 57B, 1486 (1924)
Majima, Morio.,Annalen., 476,171,194,203 (1929)
Tamura., ibid, 533,183 (1937)
Structure:
Keith, Pelletier., Chem. Commun., 993 (1967)
Keith, Pelletier., ibid, 161 (1968)
Keith, Pelletier., 1. Org. Chem., 33, 2497 (1968)
GUAYEWUANINE B 上流と下流の製品情報
原材料
準備製品