KI16425 化学特性,用途語,生産方法
外観
白色~わずかにうすい褐色、結晶~粉末
溶解性
エタノールに溶ける。
説明
Lysophosphatidic acid (LPA) is a bioactive lipid mediator that signals through five distinct G protein-
coupled receptors (LPA
1-5). Ki16425 is a LPA receptor antagonist with selectivity for LPA
1 and LPA
3. It exhibits K
i values of 0.34, 6.5, and 0.93 μM for the human LPA
1, LPA
2, and LPA
3 receptors, respectively, as determined by measuring inositol phosphate production in RH7777-
transfected cells. Ki1642, at 10 μM, significantly blocks the response of a variety of cancer cell lines to LPA-
induced cell migration.
使用
Ki16425 is a competitive, potent and reversible antagonist to LPA1, LPA2 and LPA3.
Biochem/physiol Actions
Ki 16425 possesses a short-lived inhibitory activity. It has been studied that Ki 16425 is effective in the inhibition of neuropathic pain‐like behaviors.
KI16425 上流と下流の製品情報
原材料
準備製品