ゾフェノプリルカルシウム
ゾフェノプリルカルシウム 物理性質
- 融点 :
- >250°C
- 比旋光度 :
- D23 -67.6° (c = 1 in methanol/HCl)
- 貯蔵温度 :
- Inert atmosphere,2-8°C
- 溶解性:
- DMSO：>5mg/mL
- 外見 :
- 粉
- 色:
- ホワイトからオフホワイト
- CAS データベース:
- 81938-43-4(CAS DataBase Reference)
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
| 主な危険性 |
N |
|
|
| Rフレーズ |
50/53 |
|
|
| Sフレーズ |
60-61 |
|
|
| RIDADR |
UN 3077 9 / PGIII |
|
|
| WGK Germany |
3 |
|
|
| HSコード |
2933.99.5300 |
|
|
| 絵表示（GHS） |
|
| 注意喚起語 |
警告 |
| 危険有害性情報 |
| コード |
危険有害性情報 |
危険有害性クラス |
区分 |
注意喚起語 |
シンボル |
P コード |
| H410 |
長期的影響により水生生物に非常に強い毒性 |
水生環境有害性、慢性毒性 |
1 |
警告 |
|
P273, P391, P501 |
|
| 注意書き |
| P273 |
環境への放出を避けること。 |
| P501 |
内容物/容器を．．．に廃棄すること。 |
|
ゾフェノプリルカルシウム 価格
もっと(7)
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01TRCZ587000 |
ゾフェノプリルカルシウム塩
Zofenopril Calcium Salt |
81938-43-4 |
5mg |
￥20400 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01TRCZ587000 |
ゾフェノプリルカルシウム塩
Zofenopril Calcium Salt |
81938-43-4 |
1mg |
￥16000 |
2023-06-01 |
購入 |
|
東京化成工業
|
Z0041 |
ゾフェノプリルカルシウム >97.0%(HPLC)
Zofenopril Calcium
>97.0%(HPLC) |
81938-43-4 |
25mg |
￥16700 |
2024-03-01 |
購入 |
|
東京化成工業
|
Z0041 |
ゾフェノプリルカルシウム >97.0%(HPLC)
Zofenopril Calcium
>97.0%(HPLC) |
81938-43-4 |
100mg |
￥50200 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01TRCZ587000 |
ゾフェノプリルカルシウム塩
Zofenopril Calcium Salt |
81938-43-4 |
10mg |
￥36600 |
2024-03-01 |
購入 |
ゾフェノプリルカルシウム 化学特性,用途語,生産方法
外観
白色～うすい黄色粉末～結晶
効能
血圧降下薬, アンジオテンシン変換酵素(ACE)阻害薬
説明
Zofenopril calcium was introduced as a second-generation angiotensinconverting
enzyme (ACE) inhibitor for the treatment of acute myocardial infarction.
Zofenopril, rapidly hydrolyzed by cardiac esterase, is actually a S-benzoyl prodrug of the
active component zofenopril-sulfhydryl (zofenoprilat), the latter being the ACE inhibitor
responsible for the improvement of postischemic contractile function and for the reduction
of cardiac cell death. It was suggested that ACE inhibition alone was not sufficient to
explain the cardioprotective effects; the antioxidant properties demonstrated in vitro and in
viva could partly explain the strong anti-ischemic effects. In rats with CHF after myocardial
infarction, zofenopril attenuated ventricular enlargement and cardiac hypertrophy. It was
also shown in isolated globally ischemic rat hearts that the cardioprotective effect of
zofenopril was stereoselective. Clinical studies in healthy volunteers comparing zofenopril
with enalapril demonstrated that the rate of hydrolysis of the former was faster; at 30 or 60
mg, ACE was completely inhibited in most volunteers until 12h after administration. In
patients with anterior acute myocardial infarction, a g-week treatment with zofenopril
significantly reduced the incidence of death or severe CHF and also improved the chance
of surviving the next year.
化学的特性
Off-White to Light Yellow Crystalline Solid
使用
Angiotensin-converting enzyme ACE inhibitor. A prodrug that is de-esterified to the active inhibitor, the sulfhydryl group containing metabolite, Zofenoprilat
定義
ChEBI: An organic calcium salt that is the hemicalcium salt of zofenopril. A prodrug for zofenoprilat.
ゾフェノプリルカルシウム 上流と下流の製品情報
原材料
準備製品
ゾフェノプリルカルシウム 生産企業
Global( 180)Suppliers
ゾフェノプリルカルシウム スペクトルデータ(1HNMR)
81938-43-4(ゾフェノプリルカルシウム)キーワード:
- 81938-43-4
- L-Proline,1-[(2S)-3-(benzoylthio)-2-Methyl-1-oxopropyl]-4-(phenylthio)-, calciuM salt(2:1), (4S)-
- Zofenopril calcium, >=98.5%
- (4S)-1-[(2S)-3-(benzoylthio)-2-methyl-1-oxopropyl]-4-(phenylthio)-L-proline calcium salt
- ZOFENOPRIL CALCIUM
- ZOFENOPRIL CALCIUM SALT
- [1(S),4(S)]-1-(3-Mercapto-2-methyl-1-oxopropyl)-4-phenyl-thio-L-proline-S-benzoyl Ester Calcium Salt
- Bifril
- Zofenil
- (4s)-n-[3-(benzoylsulfanyl)-2(s)-methylpropionyl]-4-(phenylsulfanyl)-l-proline calcium salt
- [(4S)-(2S)-3-(benzoylthio)-2-methylpro-pionyl-4-(phenylthio)-L-prolinelcalcium
- ZOFENOPRILCALCIUMSALT(FORRESEARCHONLY)
- Zofenopril Calciun Salt
- (4S)-(2S)-3-(BENZOYLTHIO)-2-METHYLPRO-PIONYL-4 -(PHENYLTHIO)-L-PROLINEL CALCIUM SALT
- Bifril-d5
- [1(S),4(S)]-1-(3-Mercapto-2-Methyl-1-oxopropyl)-4-phenyl-thio-L-proline-S-benzoyl-d5 Ester CalciuM Salt
- Zofenil-d5
- SQ26991
- SQ26991;ZOPRACE
- Zoprace
- Zofenopril calcium USP/EP/BP
- Zofenopril calcium Impurities
- Zofenopril calciumQ: What is
Zofenopril calcium Q: What is the CAS Number of
Zofenopril calcium Q: What is the storage condition of
Zofenopril calcium Q: What are the applications of
Zofenopril calcium
- Calcium (2S,4S)-1-((S)-3-(benzoylthio)-2-methylpropanoyl)-4-(phenylthio)pyrrolidine-2-carboxylate
- ゾフェノプリルカルシウム
- ゾフェノプリルカルシウム塩
- rel-ビス[1-[(S*)-3-(ベンゾイルチオ)-2-メチル-1-オキソプロピル]-4α-(フェニルチオ)-L-プロリン]カルシウム