ダリフェナシン臭化水素酸塩
ダリフェナシン臭化水素酸塩 物理性質
- 融点 :
- 228-2300C
- 比旋光度 :
- 25D -30.3° (c = 1.0 in methylene chloride)
- 貯蔵温度 :
- -20°C
- 溶解性:
- DMSO：可溶20mg/mL、透明
- 外見 :
- 粉
- 色:
- 白からベージュ
- 光学活性 (optical activity):
- [α]/D +41 to +49°, c = 1 in methylene chloride
- CAS データベース:
- 133099-07-7(CAS DataBase Reference)
ダリフェナシン臭化水素酸塩 価格
もっと(12)
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01COBQA-1979 |
ダリフェナシン臭化水素酸塩
Darifenacin hydrobromide |
133099-07-7 |
1g |
￥22500 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01COBQA-1979 |
ダリフェナシン臭化水素酸塩
Darifenacin hydrobromide |
133099-07-7 |
5g |
￥67500 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
SML1102 |
ダリフェナシン 臭化水素酸塩 ≥98% (HPLC)
Darifenacin hydrobromide ≥98% (HPLC) |
133099-07-7 |
10mg |
￥12500 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
SML1102 |
ダリフェナシン 臭化水素酸塩 ≥98% (HPLC)
Darifenacin hydrobromide ≥98% (HPLC) |
133099-07-7 |
50mg |
￥62200 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01TRCD193400 |
ダリフェナシン臭化水素酸塩
Darifenacin Hydrobromide |
133099-07-7 |
25mg |
￥22200 |
2024-03-01 |
購入 |
ダリフェナシン臭化水素酸塩 化学特性,用途語,生産方法
効能
過活動膀胱用薬, ムスカリン受容体拮抗薬
説明
Darifenacin, an orally active, once a day selective M3
receptor antagonist, was launched for the treatment of overactive
bladder in patients with symptoms of urge urinary
incontinence, urgency and frequency. The drug selectively
inhibits M3 receptor in the detrusor muscle while sparing the M1 and M2 receptors that are believed to be involved
in central nervous system and cardiovascular function respectively.
The compound was originally developed by
Pfizer and licensed to Novartis and Bayer.
化学的特性
White Solid
使用
Darifenacin hydrobromide is used as a medication to treat urinary incontinence. It works by blocking the M3 muscarinic acetylcholine receptor.
定義
ChEBI: The hydrobromide salt of darifenacin. A selective antagonist for the M3 muscarinic acetylcholine receptor, which is primarily responsible for bladder muscle contractions, it is used in the management of urinary incontinence.
一般的な説明
Darfenacin (Enablex),(s)-2-{1-[2-(2,3-dihydrobenzofuran-5-yl)ethyl]-3-pyrrolidinyl}-2,2-diphen-ylacetamide, is an antimuscarinicagent that has selectivity for the M3 muscarinicsubtype receptor. By competitively blocking of the muscarinicreceptors results in a reduction of the smoothmuscle tone, allowing for greater volume of urine to bestored in the bladder. This results in less urinary incontinence,urgency, and frequency. It is a white to almostwhite, crystalline powder, with a molecular weight of507.5. Darifenacin is metabolized by the isozymesCYP2D6 and CYP3A4 with the primary metabolic routesbeing monohydroxylation of the dihydrobenzofuran ring,opening of the dihydrobenzofuran ring, and N-dealkylationof the pyrrolidine nitrogen.
ダリフェナシン臭化水素酸塩 上流と下流の製品情報
原材料
準備製品
ダリフェナシン臭化水素酸塩 生産企業
Global( 267)Suppliers
ダリフェナシン臭化水素酸塩 スペクトルデータ(1HNMR)
133099-07-7(ダリフェナシン臭化水素酸塩)キーワード:
- 133099-07-7
- 2-[(3S)-1-[2-(2,3-dihydro-1-benzofuran-5-yl)ethyl]pyrrolidin-3-yl]-2,2-diphenyl-ethanamide hydrobromide
- 2-[(3S)-1-[2-(2,3-dihydrobenzofuran-5-yl)ethyl]pyrrolidin-3-yl]-2,2-diphenyl-acetamide hydrobromide
- Darifenacine Hydrobromide
- Darifenacin hydrobro
- (3S)-1-[2-(2,3-Dihydro-5-benzofuranyl)ethyl]-α-α-diphenyl-3-pyrrolidineacetaMide HydrobroMide
- Darifenacin hydrobroMide R
- DARFENACIN HYDROBROMIDE
- (S)-3-(Carbamoyldiphenylmethyl)-1-[2-(2,3-dihydrobenzofuran-5-yl)ethyl]pyrrolidine hydrobromide
- UK 88525-04
- Darifenacin hydrobromide, >=99%
- Darifenacin HCl
- {1-[2-(2,3-dihydrobenzofuran-5-yl)ethyl]-3-pyrrolidnyl}-2,2-diphenylacetamide hydrobromide
- darifenacin hydrobromide
- DARIFENACIN HYDROBROMIDE 99.0%
- Darifenacin hydrobromide (Under R&D)
- (3S)-1-[2-(2,3-Dihydro-5-benzofuranyl)ethyl]-a-a-diphenyl-3-pyrrolidineacetamide Hydrobromide
- Emsele
- Enablex
- DARIFENACIN HBR
- Darifenacin Hydrobromid
- (3S)-1-[2-(2,3-Dihydro-5-benzofuranyl)ethyl]-α-a-diphenyl-3-pyrrolidineacetamide Hydrobromide
- Emselex
- 2-[(3S)-1-[2-(2,3-dihydro-1-benzofuran-5-yl)ethyl]pyrrolidin-3-yl]-2,2-diphenylacetamide hydrobromide
- Darifenacin Hydrobromide ((3S)-1-[2-(2,3-Dihydro-5-benzofuranyl)ethyl]-a-a-diphenyl-3-pyrrolidineacetamide Hydrobromide
- (S)-2-[1-[2-(2,3-Dihydrobenzfuran-5-yl)ethyl]-3-pyrrolidinyl]-2,2-diphenylacetamide HBr
- 3-Pyrrolidineacetamide, 1-[2-(2,3-dihydro-5-benzofuranyl)ethyl]-α,α-diphenyl-, hydrobromide (1:1), (3S)-
- Darifenacin hydrobromide USP/EP/BP
- Darifenacin Hydrobromide (10mM in DMSO)
- Darifenacin HBr (UK88525)
- Darifenacin D4 hydrochlorideQ: What is
Darifenacin D4 hydrochloride Q: What is the CAS Number of
Darifenacin D4 hydrochloride Q: What is the storage condition of
Darifenacin D4 hydrochloride Q: What are the applications of
Darifenacin D4 hydrochloride
- ダリフェナシン臭化水素酸塩
- ダリフェナシン臭化水素酸塩 (JAN)
- 臭化水素酸ダリフェナシン