An enzyme that is located in catecholamine-synthesizing cells and is responsible
for the hydroxylation of L-tyrosine to L 3,4-dihydroxyphenylalanine (L-dopa). This is the initial and rate-limiting step in the biosynthetic pathway for catecholamines (dopamine, norepinephrine, and epinephrine). In addition to hydroxylating tyrosine using biopterin as a coenzyme, this enzyme can also
hydroxylate phenylalanine to tyrosine. The enzyme is located in the cytosol of catecholamine neurons and has a Km for tyrosine that is in the micromolar range.
용도
Anti-th antibody produced in rabbit has been used in:
western blotting (1:1000)
whole retinal flat-mount immunolabelling (1:500)
immunofluorescence (2:1000)
immunohistochemistry (2:1000)
일반 설명
Tyrosine hydroxylase?(TH) is a cytoplasmic enzyme. The TH gene codes for a monooxygenase.
