파시레오타이드
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파시레오타이드 속성
- 끓는 점
- 1351.4±65.0 °C(Predicted)
- 밀도
- 1.36±0.1 g/cm3(Predicted)
- 저장 조건
- Store at -20°C
- 용해도
- DMSO에 용해됨
- 물리적 상태
- 가루
- 산도 계수 (pKa)
- 11.86±0.46(Predicted)
- 색상
- White to off-white
- 시퀀스
- cyclo[Tyr(Bzl)-Phe-Hyp(Bom)-Phg-D-Trp-Lys]
- InChIKey
- VMZMNAABQBOLAK-PHODJXESNA-N
- CAS 데이터베이스
- 396091-73-9
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
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| 신호 어: | Warning | ||||||||||||||||||||||||||||||||||||||||||
| 유해·위험 문구: |
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| 예방조치문구: |
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파시레오타이드 C화학적 특성, 용도, 생산
개요
In April 2012, the European Commission approved pasireotide for the treatment of Cushing’s Disease (CD) in adult patients who have not responded to surgical interventionor forwhomsurgery is not anoption.Pasireotide was approved for the same indication by the US FDA in December of 2012. Pasireotide (also known as SOM230) is a cyclohexapeptide that acts as a somatostatin analogue to inhibit the release of ACTH. Somatostatins are cyclic peptides of 14 and 28 amino acids that play animportant role inregulating endocrineandexocrine release inmany tissues through an inhibitory mechanism. There are five known subtypes of somatostatin receptors (SSTRs). Natural somatostatins bind with high affinity to all five subtypes, however, their therapeutic use is limited by rapid degradation in plasma. Pasireotide arose fromefforts to identify a somatostatinmimetic with long-lasting inhibitory effects. Starting with a 14-amino acid somatostatin peptide, a systematic alanine scan revealed residues that were essential for receptor sub-type binding, including key b-turn regions and adjacent residues. Placing the key structural elements as unnatural amino acids in a cyclohexapeptide backbone gave pasireotide.용도
Pasireotide can be used in biological study of long-term treatment of Cushing''s disease with pasireotide, 5-yr results from open-label extension study of Phase III trial.Clinical Use
Pasireotide, also known as SOM230, is a cyclic, hexameric peptide developed by Novartis which exhibits somatostatin-like activity as an antisecretory agent used in the treatment of Cushing’s disease. Pasireotide activates a broad range of somatostatin receptors, and in particular displays a significantly higher binding affinity for somatostatin receptors 1, 3, and 5 than its competitor somatostatin-mimic octreotide in vitro, as well as a comparable binding affinity for somatostatin receptor 2. Pasireotide is more potent than somatostatin in inhibiting the secretion of human growth hormone (HGH), glucagon, and insulin.부작용
The Side Effects of Pasireotide: Headache, hair loss, dizziness, diarrhea, gas, bloating, constipation, muscle pain, swelling of arms/legs, and redness/pain/swelling/itching/bleeding at injection site may occur.파시레오타이드 준비 용품 및 원자재
원자재
준비 용품
파시레오타이드 공급 업체
글로벌( 125)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Shandong Huizhihan Supply Chain Co., Ltd | +86-13363081709 +86-13363000288 |
3957328362@qq.com | China | 300 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8615965530500 |
nickzhang@hangyubiotech.com | China | 10987 | 58 |
| Nantong Guangyuan Chemicl Co,Ltd | +undefined17712220823 |
admin@guyunchem.com | China | 615 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 |
admin@nexconn.com | China | 10406 | 58 |
| BOC Sciences | +1-631-485-4226 |
inquiry@bocsci.com | United States | 19552 | 58 |
| Shanghai Longyu Biotechnology Co., Ltd. | +8619521488211 |
info@longyupharma.com | China | 2556 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 |
sales@alchempharmtech.com | United States | 63687 | 58 |
| TopScience Biochemical | 00852-68527855 |
info@itopbiochem.com | China Hong Kong | 902 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 |
factory@coreychem.com | China | 29805 | 58 |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-0519-85551759 +8613506123987 |
marketing1@neostarunited.com | China | 8829 | 58 |