아디핀산
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아디핀산 속성
- 녹는점
- 151-154 °C(lit.)
- 끓는 점
- 265 °C100 mm Hg(lit.)
- 밀도
- 1,36 g/cm3
- 증기 밀도
- 5 (vs air)
- 증기압
- 1 mm Hg ( 159.5 °C)
- 굴절률
- 1.4880
- FEMA
- 2011 | ADIPIC ACID
- 인화점
- 385 °F
- 저장 조건
- Store below +30°C.
- 용해도
- 메탄올: 0.1 g/mL, 투명, 무색
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 산도 계수 (pKa)
- 4.43(at 25℃)
- 색상
- 하얀색
- 수소이온지수(pH)
- 3.74(1 mM solution);3.22(10 mM solution);2.71(100 mM solution);
- 냄새
- 와트시. 단사정계 프리즘, 실습. 냄새 없는
- 수용성
- 1.44 g/100 mL (15 ºC)
- JECFA Number
- 623
- Merck
- 14,162
- BRN
- 1209788
- 노출 한도
- ACGIH: TWA 5 mg/m3
- Dielectric constant
- 1.8(Ambient)
- 안정성
- 안정적인. 피해야 할 물질로는 암모니아, 강산화제 등이 있습니다.
- InChIKey
- WNLRTRBMVRJNCN-UHFFFAOYSA-N
- LogP
- 0.09 at 25℃
- CAS 데이터베이스
- 124-04-9(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xi | ||
---|---|---|---|
위험 카페고리 넘버 | 36-41 | ||
안전지침서 | 26-39-24/25 | ||
WGK 독일 | 1 | ||
RTECS 번호 | AU8400000 | ||
자연 발화 온도 | 788 °F | ||
TSCA | Yes | ||
HS 번호 | 29171210 | ||
유해 물질 데이터 | 124-04-9(Hazardous Substances Data) | ||
독성 | LD50 orally in Rabbit: 5700 mg/kg LD50 dermal Rabbit > 7940 mg/kg | ||
기존화학 물질 | KE-03754 |
아디핀산 C화학적 특성, 용도, 생산
물성
에탄올에는 쉽게 녹으며, 아세톤에 녹고 에테르에는 거의 녹지 않는다. 금속염이 많은 것은 물에 녹는다.용도
아디 핀산은 밑창, PU 크기, 나일론 66 및 일부 용제의 기본 용액 생산에 사용할 수 있습니다. 의학에서 Adipic Acid는 산성 매체에서의 방출에 영향을주지 않고 기공 형성 제로서 사용될 수 있습니다.용도
1) 합성 섬유 특히 66-나일론의 제조 원료로서 중요하다. 2) 알키드 수지, 폴리에스테르의 한 성분. 3) 고급 알코올과의 디에스테르는 가소제. 4) 산의 1차 표준 물질로서 알칼리 표준액의 표준 적정에 사용된다.용도
유화제, 안정제, pH조정제, 향료고정제로 사용된다. 베이킹파우더의 산제, 치즈, 캔디, 젤리의 산미료, 알코올 음료의 향미증진제로 사용된다. 잼, 젤리의 겔 형성을 위한 pH조절제로 사용된다.순도시험
(1) 비소 : 이 품목을 비소시험법에 따라 시험할 때, 그 양은 4.0ppm 이하이어야 한다.
(2) 납 : 이 품목 5.0g을 취하여 원자흡광광도법 또는 유도결합플라즈마발광광도법에 따라 시험할 때, 그 양은 2.0ppm 이하이어야 한다.
(3) 수은 : 이 품목을 수은시험법에 따라 시험할 때, 그 양은 1.0ppm 이하이어야 한다.
(4) 융점 : 이 품목의 융점은 151.5~154.0℃이어야 한다.
정량법
이 품목 1.5g을 정밀히 달아 250mL 공전삼각플라스크에 넣고 끓여 식힌 물 75mL를 넣은 후 0.5N 수산화나트륨용액으로 적정한다(지시약 : 페놀프탈레인시액 2~3방울).
0.5N 수산화나트륨 용액 1mL = 36.54mg C6H10O4
개요
Adipic acid is a crystalline powder with practically no odor. It has the lowest acidity of any of the acids commonly used in foods and has excellent buffering capacity in the range of pH 2.5 to 3.0. Like succinic and fumaric acid, adipic acid is practically nonhygroscopic. Its addition to foods imparts a smooth, tart taste. In grape-flavored products, it adds a lingering supplementary flavor and gives an excellent set to food powders containing gelatin. As a result, adipic acid has found a wide number of uses as an accidulant in dry powdered food mixtures, especially in those products having delicate flavors and where addition of tang to the flavor is undesirable.![Adipic acid](https://www.chemicalbook.com/NewsImg/2020-03-19/2020319174036811.jpg)
Its aqueous solutions have the lowest acidity of any of the common food acids. For concentrations from 0.5 to 2.4 g/100 mL, the pH of its solution varies less than half a unit. Hence, it can be used as a buffering agent to maintain acidities within the range of 2.5 to 3.0. This is highly desirable in certain foods, yet the pH is low enough to inhibit the browning of most fruits and other foodstuffs.
화학적 성질
Adipic acid is the organic compound with the formula (CH2)4(COOH)2. From the industrial perspective, it is the most important dicarboxylic acid: About 2.5 billion kilograms of this white crystalline powder are produced annually, mainly as a precursor for the production of nylon. Adipic acid otherwise rarely occurs in nature.물리적 성질
Adipic acid is a straight-chain dicarboxylic acid that exists as a white crystalline compound at standard temperature and pressure. Adipic acid is one of the most important industrial chemicals and typically ranks in the top 10 in terms of volume used annually by the chemical industry.출처
Reported found as a minor constituent in butter, and has been found in other fats as a product of oxidative rancidity. It also occurs in beet juice, pork fat, guava fruit (Psidium guajava L.), papaya (Carica papaya L.) and raspberry (Rubus idaeus L.).용도
Adipic Acid is primarily used in the synthesis of nylon. It has been used as a reagent in the solid-state polymerization of nylon analogs.정의
ChEBI: An alpha,omega-dicarboxylic acid that is the 1,4-dicarboxy derivative of butane.제조 방법
Adipic acid is produced from a mixture of cyclohexanol and cyclohexanone called "KA oil", the abbreviation of "ketone-alcohol oil." The KA oil is oxidized with nitric acid to give adipic acid, via a multistep pathway. Early in the reaction the cyclohexanol is converted to the ketone, releasing nitrous acid:HOC6H11 + HNO3 → OC6H10 + HNO2 + H2O
Among its many reactions, the cyclohexanone is nitrosated, setting the stage for the scission of the C- C bond:
HNO2 + HNO3 → NO+NO3- + H2O
OC6H10 + NO+→ OC6H9-2 - NO + H+
Side products of the method include glutaric and succinic acids.
Related processes start from cyclohexanol, which is obtained from the hydrogenation of phenol.
생산 방법
Adipic acid is prepared by nitric acid oxidation of cyclohexanol or cyclohexanone or a mixture of the two compounds. Recently, oxidation of cyclohexene with 30% aqueous hydrogen peroxide under organic solvent- and halide-free conditions has been proposed as an environmentally friendly alternative for obtaining colorless crystalline adipic acid.화학 반응
Adipic acid is a dibasic acid (can be deprotonated twice). Its pKa's are 4.41 and 5.41.With the carboxylate groups separated by four methylene groups, adipic acid is suited for intramolecular condensation reactions. Upon treatment with barium hydroxide at elevated temperatures, it undergoes ketonization to give cyclopentanone.
일반 설명
Adipic acid is a white crystalline solid. Adipic acid is insoluble in water. The primary hazard is the threat to the environment. Immediate steps should be taken to limit its spread to the environment. Adipic acid is used to make plastics and foams and for other uses.공기와 물의 반응
Dust may form explosive mixture with air [USCG, 1999]. Insoluble in water.건강위험
Exposures to adipic acid cause pain, redness of the skin and eyes, tearing or lacrimation. Adipic acid has been reported as a non-toxic chemical. Excessive concentrations of adipic acid dust are known to cause moderate eye irritation, irritation to the skin, and dermatitis.It may be harmful if swallowed or inhaled. It causes respiratory tract irritation with symptoms of coughing, sneezing, and blood-tinged mucous.Pharmaceutical Applications
Adipic acid is used as an acidifying and buffering agent in intramuscular, intravenous and vaginal formulations. It is also used in food products as a leavening, pH-controlling, or flavoring agent.Adipic acid has been incorporated into controlled-release formulation matrix tablets to obtain pH-independent release for both weakly basicand weakly acidic drugs.It has also been incorporated into the polymeric coating of hydrophilic monolithic systems to modulate the intragel pH, resulting in zero-order release of a hydrophilic drug.The disintegration at intestinal pH of the enteric polymer shellac has been reported to improve when adipic acid was used as a pore-forming agent without affecting release in the acidic media.Other controlled-release formulations have included adipic acid with the intention of obtaining a late-burst release profile.
Safety Profile
Poison by intraperitoneal route. Moderately toxic by other routes. A severe eye irritant. Combustible when exposed to heat or flame; can react with oxidzing materials. When heated to decomposition it emits acrid smoke and fumes.Safety
Adipic acid is used in pharmaceutical formulations and food products. The pure form of adipic acid is toxic by the IP route, and moderately toxic by other routes. It is a severe eye irritant, and may cause occupational asthma.LD50 (mouse, IP): 0.28 g/kg
LD50 (mouse, IV): 0.68 g/kg
LD50 (mouse, oral): 1.9 g/kg
LD50 (rat, IP): 0.28 g/kg
LD50 (rat, oral): >11 g/kg
잠재적 노출
Workers in manufacture of nylon, plasticizers, urethanes, adhesives, and food additives저장
Adipic acid is normally stable but decomposes above boiling point. It should be stored in a tightly closed container in a cool, dry place, and should be kept away from heat, sparks, and open flame.운송 방법
UN3077 Environmentally hazardous substances, solid, n.o.s., Hazard class: 9; Labels: 9-Miscellaneous hazardous material, Technical Name RequiredPurification Methods
For use as a volumetric standard, adipic acid is crystallised once from hot water with the addition of a little animal charcoal, dried at 120o for 2hours, then recrystallised from acetone and again dried at 120o for 2hours. Other purification procedures include crystallisation from ethyl acetate and from acetone/petroleum ether, fusion followed by filtration and crystallisation from the melt, and preliminary distillation under vacuum. [Beilstein 2 IV 1956.]비 호환성
Adipic acid is incompatible with strong oxidizing agents as well as strong bases and reducing agents. Contact with alcohols, glycols, aldehydes, epoxides, or other polymerizing compounds can result in violent reactions.폐기물 처리
Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed주의 사항
Occupational workers should avoid contact of the adipic acid with the eyes, avoid breathing dust, and keep the container closed. Workers should use adipic acid only with adequate ventilation. Workers should wash thoroughly after handling adipic acid and keep away from heat, sparks, and flame. Also, workers should use rubber gloves and laboratory coats, aprons, or coveralls, and avoid creating a dust cloud when handling, transferring, and cleaning up.Regulatory Status
GRAS listed. Included in the FDA Inactive Ingredients Database (IM, IV, and vaginal preparations). Accepted for use as a food additive in Europe. Included in an oral pastille formulation available in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.아디핀산 준비 용품 및 원자재
원자재
Organic ester
구리
메타보릭산
1,3-부타디엔
시클로헥센
사이클로헥세인
구리 아세트산 모노수화물
오산화 바나듐
질산
사이클로헥산올
수산화나트륨
Bromide
사이클로헥사논
초산 망간(II)
준비 용품
디에틸2,5-디브로모헥산디오에이트
다이메틸 지방질
2,2-DIMETHYLCYCLOPENTANONE
폴리우레탄 중합체
PolyesterPolyol
Water-soluble resin
polyesters containing quarternary ammonium groups
아디프산디에틸에스테르
나일론 6
Monostearin
2,5-비스(5-사차-뷰틸벤족사졸-2-일)싸이오펜
헥사메틸렌디이소시아네이트
아디프산디옥틸에스테르
6-에톡시-6-옥소헥사노익산
사이클로펜타놀
나일론 6/6
아디프산디노르말부틸에스테르
아디포니트릴
헥사메틸렌디아민
글루타릭 안하이드라이드
디옥틸아디페이트
글루타르산
디메타크릴레이트 디에틸렌글리콜
사이클로펜타논
2,5-티오펜이카복실산
테트라코산산
아디포일클로라이드
아디핀산 공급 업체
글로벌( 1101)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 |
info@dycnchem.com | China | 52861 | 58 |
ShanDong Look Chemical Co.,Ltd. | +8617653113219 |
sales01@sdlookchemical.com | China | 2739 | 58 |
Shandong Huisheng Import & Export Co., Ltd. | +86-13176845580 +86-13176845580 |
da@zhongda-biotech.com | China | 248 | 58 |
Hebei Shengyang Water Conservancy Engineering Co., Ltd. | +8615373025980 |
clara@hbshengyang.com | China | 873 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 |
sales@aladdinsci.com | United States | 52927 | 58 |
Hebei Guanlang Biotechnology Co,.LTD | +8619930503252 |
daisy@crovellbio.com | China | 5828 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 20294 | 58 |
airuikechemical co., ltd. | +undefined86-15315557071 |
sales06@airuikechemical.com | China | 983 | 58 |
hebei hongtan Biotechnology Co., Ltd | +86-86-1913198-3935 +8617331935328 |
sales03@chemcn.cn | China | 973 | 58 |
Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618740459177 |
sarah@tnjone.com | China | 1143 | 58 |