1-benzyl-N-(furan-2-ylmethyl)benzimidazol-2-amine 구조식 이미지
카스 번호:
831234-13-0
상품명:
1-benzyl-N-(furan-2-ylmethyl)benzimidazol-2-amine
동의어(영문):
AC1903;AC1903 ，S0977;AC1903 AC-1903;AC1903 >=98% (HPLC);AC1903, 10 mM in DMSO;1-benzyl-N-(furan-2-ylmethyl)benzimidazol-2-amine;1-Benzyl-N-(2-furylmethyl)-1H-benzimidazol-2-amine;1-benzyl-N-(furan-2-ylmethyl)-1H-benzo[d]imidazol-2-amine;1-Benzyl-N-[(furan-2-yl)methyl]-1H-1,3-benzodiazol-2-amine;1H-Benzimidazol-2-amine, N-(2-furanylmethyl)-1-(phenylmethyl)-
눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
P330
입을 씻어내시오.
P332+P313
피부 자극이 생기면 의학적인 조치· 조언을 구하시오.
P337+P313
눈에 대한 자극이 지속되면 의학적인 조치· 조언를 구하시오.
P362
오염된 의복을 벗고 세척 후에 재사용하기
P403+P233
용기는 환기가 잘 되는 곳에 단단히 밀폐하여 저장하시오.
P405
밀봉하여 저장하시오.
P501
...에 내용물 / 용기를 폐기 하시오.
NFPA 704
0
2
0
1-benzyl-N-(furan-2-ylmethyl)benzimidazol-2-amine C화학적 특성, 용도, 생산
개요
AC1903 is an inhibitor of transient receptor potential canonical channel 5 (TRPC5; IC50 = 14.7 μM). It is selective for TRPC5 over TRPC4 and TRPC6 at concentrations up to 100 and 30 μM, respectively. It inhibits TRPC5 in a concentration-dependent manner in HEK293 cells when used at concentrations ranging from 1 to 100 μM. AC1903 (30 μM) inhibits angiotensin II-induced production of reactive oxygen species (ROS) in wild-type podocytes and podocytes expressing a mutant angiotensin II type 1 (AT1) receptor that cannot be inactivated and endocytosed. It also suppresses proteinuria as well as reduces pseudocyst formation and podocyte loss in an AT1 receptor transgenic rat model of kidney disease when administered at a dose of 50 mg/kg twice per day. In a model of hypertension-induced focal segmental glomerulosclerosis (FSGS) using Dahl salt-sensitive rats, AC1903 decreases the rate of proteinuria when administered at the beginning of a high-salt diet and prevents progression when administered one week following initiation of a high-salt diet.
1-benzyl-N-(furan-2-ylmethyl)benzimidazol-2-amine 준비 용품 및 원자재
원자재
준비 용품
1-benzyl-N-(furan-2-ylmethyl)benzimidazol-2-amine 공급 업체
