Gonadorelin acetate

Gonadorelin acetate 속성

Gonadorelin acetate C화학적 특성, 용도, 생산

개요

Gonadorelin Acetate is another name for gonadotropin-releasing hormone (GnRH). It is a synthetic decapeptide prepared using solid phase peptide synthesis.
Gonadorelin, also known as GnRH or LHRH, is produced by neuroendocrine cells within the hypothalamus. The hormone is secreted pulsatilely. Gonadorelin induces the release of LH and FSH from the anterior pituitary.
After a transient increase, continuous administration of gonadorelin results in downregulation of LH and FSH levels followed by a suppression of ovarian and testicular steroid biosynthesis.

용도

Gonadorelin Acetate is used in various agricultural and biological studies. It was used to study ovulation synchronization in dairy cows.
Synthetic GnRH (gonadorelin hydrochloride [Factrel]) is marketed for diagnostic purposes to differentiate between pituitary and hypothalamic defects in patients with delayed puberty and hypogonadotropic hypogonadism. After a baseline serum LH is drawn, a single 100-mcg GnRH dose is administered subcutaneously or intravenously. An increase in serum LH of greater than 10 mIU/ml is considered a positive response. Synthetic GnRH (gonadorelin acetate [Lutrepulse]) is marketed for the treatment of infertile women who are anovulatory and have GnRH deficiency. In this protocol, a pump administers GnRH in pulses to promote a physiologic cycle. Because of the complexity of administration, this treatment modality was rarely used, and this product is no longer available in the United States.

주요 응용

Ovarian follicular cysts (veterinary medicine)
Use in reproduction medicine
Diagnosis of the hypothalamic-pituitary-gonadal axis function
Cryptorchism
Synchronization of ovulation (veterinary medicine)

Indications

Gonadorelin is a synthetic decapeptide with a structure identical with the natural Gonadotrophin Releasing Hormone (Gn-RH) in mammalian species.
Gonadorelin is recommended for the treatment of reproductive disorders associated with ovarian cysts and for improvement of fertility in cows and for the induction of ovulation in rabbits. The mechanism of action underlying the therapeutic use is the stimulation of the release from and also the synthesis of LH and FSH in the anterior pituitary gland.

생물학적 활성

Gonadorelin is a tropic hormone and agonist of the gonadotropin-releasing hormone receptor (GNRHR; Ki = 13 nM in CHO cells expressing the human receptor). It stimulates luteinizing hormone (LH) and follicle- stimulating hormone (FSH) release from rat anterior pituitary cultures when administered at a dose of 0.1 μg. It also stimulates LH release from bovine anterior pituitary cultures at a concentration of 1 μM. In vivo, gonadorelin induces ovulation in rats pretreated with fluphenazine (Item No. 23555; ED50 = 610.3 ng/kg). Formulations containing gonadorelin have been used as diagnostic agents to assess pituitary gland function.

부작용

Gonadorelin side effects: headache; flushing; nausea or abdominal discomfort; dizziness or lightheadedness; pain, swelling, or itching at the injection site; or. skin rash.

Safety Profile

A poison by intravenous route. Moderately toxic by ingestion and subcutaneous routes. Experimental reproductive effects. When heated to decomposition it emits acrid smoke and irritating vapors.

Gonadorelin acetate 준비 용품 및 원자재

원자재

준비 용품

Gonadorelin acetate 공급 업체

공급자	전화	이메일	국가	제품 수	이점
Cellmano Biotech Limited	0551-65326643 18156095617	info@cellmano.com	China	995	58
Qingdao Xinli Technology Development Co., Ltd.	+8616632313095	xinlikeji01@qdxlchem.com	China	124	58
hebei hongtan Biotechnology Co., Ltd	+852-6619 3215 +86-17731935328	sales03@chemcn.cn	China	970	58
Shandong Huizhihan Supply Chain Co., Ltd	+86-13363081709 +86-13363000288	3957328362@qq.com	China	300	58
American HealthyMorph LLC	+85269498027	nancyyuan133@163.com	China	169	58
Hebei Jiafan Trading Company Limited	+86-15354498258	sales01@jiafan88.com	China	122	58
Hebei Chuanghai Biotechnology Co., Ltd	+8617732866630	abby@chuanghaibio.com	China	8773	58
Hebei Mujin Biotechnology Co.,Ltd	+86-13288715578	sales@hbmojin.com	China	12749	58
Shanghai Yunao International Trade Co., Ltd	+8617621705551	asdf@shanghaihg.cn	China	264	58
Wuhan Han Sheng New Material Technology Co.，Ltd	+8617798174412	admin01@hsnm.com.cn	China	2097	58

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