2,6-Dichlorophenylacetic acid
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2,6-Dichlorophenylacetic acid 속성
- 녹는점
- 158-161 °C (lit.)
- 끓는 점
- 294.45°C (rough estimate)
- 밀도
- 1.3806 (rough estimate)
- 굴절률
- 1.5490 (estimate)
- 저장 조건
- Sealed in dry,Room Temperature
- 용해도
- DMSO(약간 용해됨), 메탄올(약간 용해됨)
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 산도 계수 (pKa)
- 3.80±0.10(Predicted)
- 색상
- 흰색에서 황백색까지
- BRN
- 1952744
- InChI
- InChI=1S/C8H6Cl2O2/c9-6-2-1-3-7(10)5(6)4-8(11)12/h1-3H,4H2,(H,11,12)
- InChIKey
- SFAILOOQFZNOAU-UHFFFAOYSA-N
- SMILES
- C1(CC(O)=O)=C(Cl)C=CC=C1Cl
- CAS 데이터베이스
- 6575-24-2(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | Xi | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 36/37/38 | ||
| 안전지침서 | 37/39-26-26/37/39-36 | ||
| WGK 독일 | 3 | ||
| 위험 참고 사항 | Irritant | ||
| HS 번호 | 29163900 |
2,6-Dichlorophenylacetic acid C화학적 특성, 용도, 생산
화학적 성질
white crystalline powder용도
2,6-Dichlorophenylacetic acid is an inhibitor of isopenicillin N synthase (IPNS) and acyl-CoA: 6-APA acyltransferase. 2,6-Dichlorophenylacetic acid is also part of a group of phenylacetate derivatives that have cytostatic activity against tumour cells.제조 방법
The preparation of the 2, 6-dichlorophenylacetic acid:the method comprises the following steps: 2, 6-dichlorotoluene is used as a raw material, and is catalyzed by a complex catalyst formed by transition metal and a ligand (wherein, a transition metal catalyst precursor is preferably palladium chloride, an oxidant is preferably TBP (tert-butyl peroxy ether), and a ligand is preferably Xantphos (4, 5-bis (diphenylphosphino) -9, 9-dimethyl xanthene)) in the presence of an alcohol and a catalyst and an oxidant to obtain 2, 6-dichlorophenylacetic acid, and the ethyl 2, 6-dichlorophenylacetate is prepared by hydrolysis and acidification, wherein the total yield is 68.4%. See patent document US2013303798, the reaction procedure is described as synthetic route 1.
In the above synthetic route 1, the preparation process of the intermediate ethyl 2, 6-dichlorophenylacetate requires the use of carbon monoxide for high-temperature and high-pressure reaction, and has poor operation safety, high equipment requirement, high cost, and is not favorable for cost reduction and green production of 2, 6-dichlorophenylacetic acid.
Purification Methods
Crystallise the acid from aqueous EtOH. [Beilstein 9 III 2272.]2,6-Dichlorophenylacetic acid 준비 용품 및 원자재
원자재
2,6-Dichlorobenzyl acetonitrile
2,2,6,6-테트라클로로사이클로헥산-1-온
3,5-디클로로-4-메틸벤조산
2,4-디클로로-3-메틸벤조산
Benzeneacetic acid, 2,6-dichloro-, ethyl ester
2,6-디클로로벤질클로라이드
말론산 디에틸
2,6-디클로로아닐린
carbon monoxide
2,6-디클로로톨루엔
이산화탄소
준비 용품
2,6-Dichlorophenylacetic acid 공급 업체
글로벌( 356)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 |
sales1@chuanghaibio.com | China | 5892 | 58 |
| Hebei Weibang Biotechnology Co., Ltd | +8617732866630 |
bess@weibangbio.com | China | 18153 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 |
sales@capot.com | China | 29791 | 60 |
| Jinan Finer Chemical Co., Ltd | +86-531-88989536 +86-15508631887 |
sales@finerchem.com | China | 2963 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 +8618959220845 |
sales@amoychem.com | China | 6383 | 58 |
| Changzhou Ditong Chemical Co.,Ltd | +86-0519-88299272 |
info@edengenechem.com | China | 2158 | 58 |
| Xi'an Kono chem co., Ltd., | 029-86107037 13289246953 |
info@konochemical.com | China | 2993 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 |
overseasales1@yongstandards.com | United States | 14332 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 |
sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 |
sales@chemwish.com | CHINA | 10821 | 58 |
2,6-Dichlorophenylacetic acid 관련 검색:
4-히드록시페닐아세트산 2-히드록시페닐아세트산 4-메톡시페닐초산 페닐초산 클로로벤질산 α,α-디클로로벤젠아세트산 에틸
2,6-DICHLOROPHENYLACETIC ACID METHYL ESTER
2,6-DICHLOROPHENYLACETAMIDE
Benzeneacetamide, N-(aminoiminomethyl)-2-chloro-
GUANFACINE HCL
Guanidine hydrochloride
3,4-DICHLOROPHENYLACETIC ACID METHYL ESTER
METHYL 2,3-DICHLOROPHENYLACETATE
2,3-DICHLOROPHENYLACETIC ACID,2,3-DICHLOROPHENYLACETIC ACID 99%
2,4-DICHLOROPHENYLACETIC ACID METHYL ESTER,2,4-DICHLOROPHENYLACETIC ACID METHYL ESTER STANDARD
2,4-Dichlorophenylacetic acid
2,6-Dichlorophenylacetic acid nitrile
3,4-DICHLOROPHENYLACETIC ACID,3,4-Dichlorophenylacetic acid ,99%