프로피온일 염화물
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프로피온일 염화물 속성
- 녹는점
- -94 °C
- 끓는 점
- 77-79 °C (lit.)
- 밀도
- 1.059 g/mL at 25 °C (lit.)
- 증기 밀도
- 3.2 (vs air)
- 증기압
- 106 hPa (20 °C)
- 굴절률
- n
20/D 1.404(lit.)
- 인화점
- 53 °F
- 저장 조건
- Store below +30°C.
- 물리적 상태
- 액체
- 색상
- 투명한
- pH 범위
- <7.0
- 폭발한계
- 3.6-11.9%(V)
- 수용성
- 물과 반응
- 어는점
- -94℃
- 감도
- Moisture Sensitive
- Merck
- 14,7828
- BRN
- 385632
- 노출 한도
- ACGIH: TWA 0.1 ppm
OSHA: TWA 0.1 ppm(0.4 mg/m3)
NIOSH: IDLH 2 ppm; TWA 0.1 ppm(0.4 mg/m3); Ceiling 0.2 ppm(0.8 mg/m3)
- InChIKey
- RZWZRACFZGVKFM-UHFFFAOYSA-N
- CAS 데이터베이스
- 79-03-8(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | F,C | ||
---|---|---|---|
위험 카페고리 넘버 | 11-14-34-20/22 | ||
안전지침서 | 9-16-26-45 | ||
유엔번호(UN No.) | UN 1815 3/PG 2 | ||
WGK 독일 | 1 | ||
RTECS 번호 | UG6657000 | ||
자연 발화 온도 | 270 °C | ||
TSCA | Yes | ||
위험 등급 | 3 | ||
포장분류 | II | ||
HS 번호 | 29051900 | ||
HS 번호 | 29399990 | ||
유해 물질 데이터 | 79-03-8(Hazardous Substances Data) | ||
독성 | LD50 orally in Rabbit: 823 mg/kg | ||
기존화학 물질 | KE-29372 |
프로피온일 염화물 C화학적 특성, 용도, 생산
화학적 성질
Propionyl chloride is a colorless to light yellow, volatile, and readily flammable liquid, whose vapors hydrolyze in moist air. It is corrosive, lachrymatory, and has a strongly pungent odor. With water and lower alcohols it reacts vigorously under solvolysis to give the acid or ester. It is used for the introduction of the propionyl group and for the synthesis of propionate esters because of its high reactivity.용도
Propionyl chloride is used as an intermediate in the production of agrochemicals and pharmaceuticals. It serves as an intermediate for dyes, textile auxiliaries and peroxide compounds. It acts as a crop protecting agent.주요 응용
Propionyl chloride is used for the introduction of the propionyl group and for the synthesis of propionate esters because of its high reactivity. It is an chemical intermediate in the preparation of various propionic acid derivatives, It can also be used:To convert anisole to 4-methoxypropiophenone and 2-methoxynaphthalene to 1-propio-2-methoxynaphthalene in the presence of Indium(III) chloride (InCl3) impregnated mesoporous Si-MCM-41 catalyst.
For chlorination in the presence of sulfuryl chloride and peroxides to form α-chloropropionyl chloride and β-chloropropionyl chloride.
In reaction with (hydroxypropyl)cellulose to form the propanoate ester, [(propionyloxy)propyl]cellulose.
제조 방법
Propionyl chloride is synthesized by reacting propionic acid with phosphorus trichloride at 40-50°C for 1h, cooling, standing, separating and distilling to obtain the product.CH3CH2COOH+PCl3→CH3CH2COCl+HOPCl2
Propionyl chloride is produced industrially by treatment of propionic acid with phosgene or thionyl chloride. The reaction occurs at ca. 50°C in the liquid phase in the presence of dialkylformamides. The product is then separated by distillation.
CH3CH2CO2H + COCl2 → CH3CH2COCl + HCl + CO2
Propionyl chloride can also be obtained by the reaction of propionic acid with PCl5.
일반 설명
Propionyl chloride appears as a colorless liquid with a pungent odor. Corrosive and very irritating to skin and eyes. Used to make other chemicals.공기와 물의 반응
Highly flammable. Propionyl chloride reacts vigorously or violently with water to form propionic acid and hydrochloric acid [Merck 11th ed. 1989].반응 프로필
Acid halides, such as Propionyl chloride, are water reactive; some are violently reactive. They are incompatible with strong oxidizing agents, alcohols, amines, and alkali. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].위험도
Strong irritant to skin.건강위험
May cause toxic effects if inhaled or ingested/swallowed. Contact with substance may cause severe burns to skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.화재위험
Flammable/combustible material. May be ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.Safety Profile
A corrosive irritant to skin, eyes, and mucous membranes. Dangerous fire hazard when exposed to heat or flame; can react vigorously with oxidizing materials. Reacts with water or steam to produce toxic and corrosive fumes. Exothermic reaction with diisopropyl ether produces much gas. The reaction may be dangerous if confmed. To fight fire, use CO2, dry chemical; do not use water. When heated to decomposition it emits lughly toxic fumes of Cl-. See also HYDROCHLORIC ACID.프로피온일 염화물 준비 용품 및 원자재
원자재
준비 용품
(4-요오도페닐)아세톤
프로파닐
4-T-부틸프로피폰
ROKITAMYCIN
PROPIONYLTHIOCHOLINE IODIDE
Ethyl butyrylacetate
이이다파리
티오프로닌
1-(2,5-디메톡시페닐)-2-옥시미노-1-프로파논
efficient polymer catalyst for acrylation-synthesis and characterigation of polyamide containing supernucleophilic reagent
1-메틸-4-[3,3,3-트리스(4-클로로페닐)프로피오닐]피페라진
2-아미노-1-(2,5-다이메톡시페닐)-1-프로파논
2-BROMO-1-(6-METHOXY-2-NAPHTHALENYL)-1-PROPANONE
클레토딤
어가녹스 MD 1024
프레드니카베이트
Pimobendan
Ethyl vinyl ketone
에틸2-(6-메톡시-2-나프틸)프로파노에이트
무수프로피온산
아미노프로펜
나프로아닐리드
6'-메톡시-2'-프로피오노나프톤
3-클로로프로피온산 클로라이드
프로피오페논
나프로P아마이드
프로피온일 염화물 공급 업체
글로벌( 436)공급 업체
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