Anti-Phosphoinositide-3-kinase, Anti-PIK3C3, Anti-Vacuolar protein sorting 34 속성
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Anti-Phosphoinositide-3-kinase, Anti-PIK3C3, Anti-Vacuolar protein sorting 34 C화학적 특성, 용도, 생산
용도
Anti-VPS34 antibody produced in rabbit has been used in immunoblotting.
일반 설명
Vacuolar protein sorting 34 (VPS34), also known as phosphatidylinositol 3-kinase catalytic subunit type 3 (PIK3C3), is encoded by the gene mapped to human chromosome 18q12.3. The encoded protein belongs to the phosphoinositide (PI)-3-kinase family. VPS34 is widely expressed in all tissues of mammals.
Biochem/physiol Actions
Vacuolar protein sorting 34 (VPS34) is a lipid kinase that phosphorylate phosphatidylinositol (PtdIns), to form phosphatidylinositol 3 phosphate (PtdIns3P). VPS34 plays a vital role in various intracellular trafficking events such as autophagy and phagosome formation. Thus, the inhibition of kinase activity of Vps34 might be considered as a potential therapeutic method for cancer treatment. VPS34 is also involved in internal vesicle formation within multivesicular endosomes, reverse transport of endosome to Golgi apparatus and membrane transport from the outer nuclear membrane towards the cell periphery. Mutation in the gene encoding VPS34 is associated with pathogenesis of schizophrenia. VPS34 plays an essential role in nutrient/amino acid induced activation of mechanistic target of rapamycin (mTOR) signaling in cultured cells and it also facilitates early embryogenesis and cell proliferation.
Anti-Phosphoinositide-3-kinase, Anti-PIK3C3, Anti-Vacuolar protein sorting 34 준비 용품 및 원자재
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Anti-Phosphoinositide-3-kinase, Anti-PIK3C3, Anti-Vacuolar protein sorting 34 공급 업체
