CLEMIZOLE
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CLEMIZOLE 속성
안전
CLEMIZOLE C화학적 특성, 용도, 생산
Originator
Allercur,Roerig,US,1960Manufacturing Process
From 13.1 g of N-p-chlorobenzyl-2-nitroaniline (MP 110°C, obtained in the form of orange-red needles, from o-nitrochlorobenzene and pchlorobenzylamine by reaction for 3 hours at 150°C) by reduction with Raneynickel and hydrogen, in which reaction the substance may be suspended in methanol or dissolved in methanol-ethyl acetate at normal pressure and at about 40°C with combination of the theoretical quantity of hydrogen, 12.2 g are obtained of o-amino-N-p-chlorobenzylaniline, which after recrystallization from aqueous methanol has a MP of 90°C.8 g of o-amino-N-p-chlorobenzylaniline and 2.8 g of pyridine are dissolved in dry ether and reacted with an ethereal solution of 3.9 g of chloracetyl chloride with cooling in a mixture of ice and common salt. 8 g of N-p-chlorobenzyl-N'- chloracetyl-o-phenylene diamine are obtained which can be worked up in the form of the crude product and, in the slightly colored form, has a MP of 130°C.
7.6 g of this compound are boiled with 3.9 g of pyrrolidine in 70 cc of toluene for some hours under reflux. After extraction by shaking with water and treatment with hydrochloric acid the hydrochloride is produced of N-pchlorobenzyl-N'-pyrrolidylacetyl-o-phenylene diamine together with some 1-pchlorobenzyl-2-N-pyrrolidylmethyl-benzimidazole. The former, after recrystallization from butanol, melts with foaming at 205°C, the latter, after recrystallization from butanol melts at 239°C to 241°C, and is in the form of white microscopic rods. Boiling in nitrobenzene converts the former compound into the latter.
Therapeutic Function
AntihistaminicCLEMIZOLE 준비 용품 및 원자재
원자재
준비 용품
CLEMIZOLE 공급 업체
글로벌( 44)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Hangzhou Lianke Biotechnology Co., Ltd. | -- |
CHINA | 6349 | 58 | |
| Beijing Luyuan Bird Biotechnology Co., Ltd. | -- |
15810802415@139.com | CHINA | 6757 | 58 |
| Shanghai Haoran Biotechnology Co., Ltd. | -- |
470003480@QQ.COM | CHINA | 6968 | 58 |
| Beijing Dongge Boye Biotechnology Co., Ltd. | -- |
1861586486@qq.com | CHINA | 6652 | 58 |
| Rhenbo (Shanghai) Biochemical Technology Co., Ltd. | -- |
CHINA | 6334 | 58 | |
| Shanghai Qincheng Biological Technology Co., Ltd. | -- |
shqcsw01@163.com | CHINA | 6369 | 58 |
| Shanghai Qiming Biological Technology Co., Ltd. | -- |
CHINA | 6503 | 58 | |
| Beijing Lebo Biotechnology Co., Ltd. | -- |
CHINA | 6057 | 58 | |
| Guangzhou Weijia Technology Co., Ltd. | -- |
WHIGA22@126.COM | CHINA | 6748 | 58 |
| Xiamen Huijia Biological Technology Co., Ltd. | -- |
CHINA | 6979 | 58 |