Ranolazine

Ranolazine C화학적 특성, 용도, 생산

개요

Dosmalfate, a heptakis(hydrogensulfate) aluminium complex of diosmin, was launched in Spain for the prevention and treatment of gastroduodenal lesions induced by NSAID therapy. Dosmalfate can be prepared from diosmin by initial treatment with a pyridine sulfur trioxide complex followed by sodium hydroxide and finally aluminium hydroxychloride. In several pharmacological models of acute and chronic ulcers, this new cytoprotective agent has demonstrated significant protection against damage to the gastric mucosa or esophagus erosion, hemorrhage or perforation. Several mechanisms of action could be involved, partly mediated by the endogenous prostaglandins. In several clinical studies with patients receiving long-term NSAID therapy for chronic inflammatory disease, the efficacy of dosmalfate in preventing gastric ulcer was high and comparable to that of misoprostol, but with significantly less adverse events. In rats and humans, dosmalfate, administered orally at very high doses, displayed a very poor absorption and consequently, a very low incidence of side effects, particularly on CNS, cardiovascular or respiratory systems.

Originator

Faes (Spain)

상표명

Diotul

Ranolazine 준비 용품 및 원자재

원자재

준비 용품

Ranolazine 공급 업체

공급자	전화	이메일	국가	제품 수	이점
Shaanxi Dideu Medichem Co. Ltd	+86-029-89586680 +86-18192503167	1026@dideu.com	China	7730	58
Sinoway Industrial co., ltd.	0592-5800732; +8613806035118	xie@china-sinoway.com	China	988	58
Foshan Nanhai Beisha Pharmaceutical Co., Ltd.	0757-85616808	bsyrylq@163.net	China	21	60
LGM Pharma	1-(800)-881-8210	inquiries@lgmpharma.com	United States	2127	70
Raw material medicin reagent co.,Ltd		sales@njromanme.com	China	4531	58
Jinan ponder chemical co. LTD	0531-0000	thinklifescience@163.com	China	19690	58
Wuhan Yanzhe Technology Co., Ltd	15527250409	wenhaotian12@163.com	China	4577	58

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