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머크SIP작용제

머크SIP작용제 구조식 이미지

카스 번호:: 635701-59-6

한글명:: 머크SIP작용제

동의어(한글):: 머크SIP작용제

상품명:: Merck SIP Agonist

동의어(영문):: CS-126;CAY10734;Merck SIP Agonist;SHQNRSGKLNMHOS-UHFFFAOYSA-N;1-(4-(5-(4-Isobutylphenyl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylic acid;butylphenyl)-1,2,4-oxadiaz1-(4-(5-(4-isool-3-yl)benzyl)azetidine-3-carboxylic acid;1-[4-[5-[4-(2-Methylpropyl)phenyl]-1,2,4-oxadiazol-3-yl]benzyl]azetidine-3-carboxylic acid;1-[[4-[5-[4-(2-methylpropyl)phenyl]-1,2,4-oxadiazol-3-ly]phenyl]methyl]-3-Azetidinecarboxylic acid;3-Azetidinecarboxylic acid, 1-[[4-[5-[4-(2-methylpropyl)phenyl]-1,2,4-oxadiazol-3-yl]phenyl]methyl]-

CBNumber:: CB51872315

분자식:: C23H25N3O3

포뮬러 무게:: 391.46

MOL 파일:: 635701-59-6.mol

속성

안전

용도

공급 업체 23

머크SIP작용제 속성

끓는 점: 565.9±60.0 °C(Predicted)

밀도: 1.228±0.06 g/cm3(Predicted)

저장 조건: Store at -20°C

용해도: DMF: 5 mg/ml; DMF:PBS (pH 7.2) (1:10): 0.1 mg/ml; Ethanol: Partially soluble

물리적 상태: 결정성 고체

산도 계수 (pKa): 2.66±0.20(Predicted)

안전

머크SIP작용제 C화학적 특성, 용도, 생산

개요

CAY10734 is an agonist of sphingosine-1-phosphate receptor 1 (S1P₁; IC₅₀ = 0.6 nM). It selectively binds S1P₁ over S1P₂, S1P₃, and S1P₄ receptors (IC₅₀s = >10,000, 12,000, and 70 nM, respectively) but does also bind S1P₅ receptors (IC₅₀ = 1 nM) in radioligand binding assays. CAY10734 reduces the number of peripheral blood lymphocytes in mice, rats, and dogs, with the maximal response achieved when administered at doses of 10, 0.5, and 0.5 mg/kg, respectively. It increases graft survival in a rat skin allograft model when administered at a dose of 5 mg/kg per day in combination with cyclosporin A (CsA; ).

머크SIP작용제 준비 용품 및 원자재

원자재

준비 용품

머크SIP작용제 공급 업체

글로벌( 23)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63711	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49391	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49739	58
Nanjing Norris-Pharm Technology Co., Ltd	13901585132	799750417@qq.com	China	8888	55
AdooQ BioScience, LLC	+1 (866) 930-6790	info@adooq.com	United States	2784	58
BOC Sciences	16314854226	info@bocsci.com	United States	9926	65
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9707	58
Nanjing KaiMubo Pharmaceutical Co., Ltd.	025-66162170		China	7183	55
Shanghai Hongye Biotechnology Co. Ltd	400-9205774	sales@glpbio.cn	China	6870	58
Henan Alpha Chemical Co., Ltd.	0371-0371-55055611 18137792234	3002694073@qq.com	China	10245	58