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JW74

JW74 구조식 이미지

카스 번호:: 863405-60-1

상품명:: JW74

동의어(영문):: JW74;JW74;JW 74;JW74 >=98% (HPLC);Inhibitor,JW74,JW-74,JW 74,inhibit,Wnt;5-(((4-(4-Methoxyphenyl)-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)thio)methyl)-3-(p-tolyl)-1,2,4-oxadiazole;4-[4-(4-Methoxyphenyl)-5-[[[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl]thio]-4H-1,2,4-triazol-3-yl]-pyridine;Pyridine, 4-[4-(4-methoxyphenyl)-5-[[[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl]thio]-4H-1,2,4-triazol-3-yl]-

CBNumber:: CB52731079

분자식:: C24H20N6O2S

포뮬러 무게:: 456.52

MOL 파일:: 863405-60-1.mol

MSDS 파일:: SDS

속성

안전

용도

공급 업체 50

JW74 속성

끓는 점: 699.4±65.0 °C(Predicted)

밀도: 1.35±0.1 g/cm3(Predicted)

저장 조건: 2-8°C

용해도: DMSO: ≥20mg/mL

산도 계수 (pKa): 1.63±0.10(Predicted)

물리적 상태: 가루

색상: 흰색에서 베이지색

안전

WGK 독일	3

JW74 C화학적 특성, 용도, 생산

개요

Tankyrases (TNKS) are poly(ADP-ribose) polymerases (PARPs) that cleave NAD⁺ to produce nicotinamide and ADP-ribose, which is then covalently attached to an acceptor protein in a process known as poly(ADP-ribosyl)ation. TNKS have key roles in the Wnt signaling pathway as part of the β-catenin destruction complex. JW 74 is an inhibitor of the catalytic PARP domain of TNKS1/2 that blocks canonical Wnt signaling with an IC₅₀ value of 790 nM. It increases the levels of Axin2 and decreases β-catenin levels in colorectal cancer (CRC) cells, leading to down-regulation of Wnt target genes. JW 74 inhibits the growth of CRC xenograft tumors in mice. JW 74 induces apoptosis and differentiation in osteosarcoma cell lines.

용도

JW 74 is an inhibitor that affects cell cycle progression and induces apoptosis and differentiation in osteosarcoma cell lines.

JW74 준비 용품 및 원자재

원자재

준비 용품

JW74 공급 업체

글로벌( 50)공급 업체

공급자	전화	이메일	국가	제품 수	이점
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32836	60
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30250	58
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd	+86-18791163155 +86-13119157289	13119157289@163.com	China	2972	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57511	58
MedChemexpress LLC	021-58955995	sales@medchemexpress.cn	United States	4863	58
ShangHai Caerulum Pharma Discovery Co., Ltd.	18149758185	sales-cpd@caerulumpharma.com	China	3466	58
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9806	58
Changzhou Hopschain Chemical Co.,Ltd.	0519-85528066 13775048983	sales@hopschem.com	China	31557	55
Tianjin Kailiqi Biotechnology Co., Ltd.	15076683720	klq@cw-bio.com	China	4182	55