Lobeglitazone Sulfate
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Lobeglitazone Sulfate 속성
- 물리적 상태
- Solid
- 색상
- White to off-white
- InChIKey
- IFBYQAMJTBOBHB-UHFFFAOYSA-N
- SMILES
- S(O)(O)(=O)=O.O(C1C=CC(OC)=CC=1)C1=NC=NC(N(C)CCOC2C=CC(CC3C(NC(=O)S3)=O)=CC=2)=C1
안전
Lobeglitazone Sulfate C화학적 특성, 용도, 생산
개요
Lobeglitazone sulfate, an oral peroxisome proliferator-activated receptor (PPARa/c) dual agonist with IC50 = 20 and 18 nM respectively, was developed by Chong Kun Dang Pharmaceutical in Korea for the treatment of diabetes. This drug is differentiated from two other PPAR agonists available—pioglitazone and rosiglitazone —which lack PPARa activity. The most likely processscale preparation of lobeglitazone sulfate follows the route described in a process communication from Chong Kun Dang Pharmaceutical.Synthesis
Commercially available 4,6-dichloropyrimidine (152) was treated with a stoichiometric equivalent of p-methoxyphenol (153) in the presence of KF in warm DMF . Upon completion of this reaction, 2-methylaminoethanol was added to the mixture to provide pyrimidine 154 in high yield. Next, alcohol 154 underwent a substitution reaction with p-fluorobenzaldehyde (155) under basic conditions to provide alkoxy benzaldehyde 156 which was converted to the benzylidene thiazolidindione 158 upon subjection to Knoevenagel conditions with 2,4-thiazolidinedione (157) in 90% yield. Finally, reduction of olefin 158 was facilitated by treatment with the Hantzsch ester (159) in the presence of silica gel followed by treatment with methanolic sulfuric acid (96%) at low temperature to ultimately furnish lobeglitazone sulfate in 90% yield.
Lobeglitazone Sulfate 준비 용품 및 원자재
원자재
준비 용품
Lobeglitazone Sulfate 공급 업체
글로벌( 30)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21622 | 55 |
| TargetMol Chemicals Inc. | +17819995354 |
marketing@targetmol.com | United States | 32302 | 58 |
| Allikang Pharmaceutical Co., LTD | 0573-87390950 13806705416 |
wzj@alicornpharma.com | China | 49 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 |
China | 4645 | 55 | |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 |
info@efebio.com | China | 9803 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 |
3008007409@qq.com | China | 71826 | 60 |
| Shanghai Rechem science Co., Ltd. | 021-31433387 15618786686 |
sales@rechemscience.com | China | 2967 | 58 |
| Shanghai SuperLan Chemcial Technique Centre | 021-2022843681 15618226720 |
lucy@atkchemical.com | China | 10017 | 58 |
| Hubei Yangxin Medical Technology Co., Ltd. | 15374522761 |
3003392093@qq.com | China | 8976 | 55 |
| Changzhou Chenhong Biotechnology Co., Ltd. | 0519-85788828 13775037613 |
sales@chemrenpharm.com | China | 3907 | 58 |