4-아미노페놀
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4-아미노페놀 속성
- 녹는점
- 188 °C
- 끓는 점
- 284 °C
- 밀도
- 1.29
- 증기압
- 0.4 hPa (110 °C)
- 굴절률
- 1.5444 (estimate)
- 인화점
- 189 °C
- 저장 조건
- 2-8°C
- 용해도
- 물: 약간 용해됨
- 물리적 상태
- 결정성 분말
- 산도 계수 (pKa)
- 5.48, 10.30(at 25℃)
- 색상
- 흰색에서 크림색으로
- 수용성
- 1.5g/100mL(20℃)
- 감도
- Air & Light Sensitive
- 분해온도
- 284 °C
- Merck
- 14,462
- BRN
- 385836
- 안정성
- 안정적이지만 공기 중에서 변색될 수 있습니다. 산, 클로로포르메이트, 강한 산화제와 호환되지 않습니다.
- InChIKey
- PLIKAWJENQZMHA-UHFFFAOYSA-N
- LogP
- -0.09-0.04 at 25℃
- CAS 데이터베이스
- 123-30-8(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xn,N | ||
---|---|---|---|
위험 카페고리 넘버 | 20/22-50/53-68-40-R68-R50/53-R20/22 | ||
안전지침서 | 28-36/37-60-61-28A-S61-S60-S36/37-S28A | ||
유엔번호(UN No.) | UN 2512 6.1/PG 3 | ||
WGK 독일 | 3 | ||
RTECS 번호 | SJ5075000 | ||
F 고인화성물질 | 8 | ||
자연 발화 온도 | >250 °C | ||
TSCA | Yes | ||
위험 등급 | 6.1 | ||
포장분류 | III | ||
HS 번호 | 28402090 | ||
HS 번호 | 29222900 | ||
유해 물질 데이터 | 123-30-8(Hazardous Substances Data) | ||
독성 | LD50 orally in Rabbit: 375 mg/kg LD50 dermal Rabbit > 10000 mg/kg | ||
기존화학 물질 | KE-01529 |
4-아미노페놀 C화학적 특성, 용도, 생산
개요
4-Aminophenol, also known as 4-hydroxyaniline, is an organic building block. Its quantification in water samples upto the detection limit of 8×10-10mol l-1 has been proposed by employing single-wall carbon nanotubes (SWNT)-nafion film coated glassy carbon electrodes. It is present as the main contaminant in pharmaceutical formulations of paracetamol. High-performance liquid chromatographic (HPLC) method with amperometric detection has been reported for its determination in various analgesic formulations. It has been reported to be formed from the reduction of 4-nitrophenol (Nip) under metal-free conditions catalyzed by N-doped graphene (NG).화학적 성질
o-Aminophenol appears as colorless needles or as white crystalline substance turning tan to brown on exposure to air. slightly soluble in water and ethanol, insoluble in benzene and chloroform, and quickly turns brown when dissolved in lye.용도
4-Aminophenol is suitable for use in the synthesis of 2,2-bis(4-aminophenoxy) benzonitrile [4-APBN], a monomer required for the preparation of series of polyamides and poly(amide-imide)s. It may be used as derivatization reagent to improve the ionization of aliphatic and aromatic aldehydes by paper spray ionization mass spectrometry.제조 방법
Conventionally 4-aminophenol was manufactured using iron-acid reduction of p-nitrobenzene. Reduction using iron-acid is a multi-step process. The modern method is the catalytic dehydrogenation of nitrobenzene to 4-aminophenol using a noble metal catalyst in the presence of an acidic medium. This method also produces aniline as a side-product. The advantage of a reduction using a noble metal catalyst is that it involves a single step reaction, an environment friendly and more efficient process, as there is no evolution of an environmentally harmful gas. Moreover, the side-product aniline is also a valuable chemical.![synthesis of 4-aminophenol](/NewsImg/2022-07-29/6379470682306911421116027.jpg)
synthesis of 4-aminophenol
주요 응용
The main and the most significant use of 4-Aminophenol is for the manufacturing of Paracetamol, an analgesic and antipyretic drug. In addition to paracetamol, it is a key element in the synthesis of pharmaceutical ingredients and important industrial chemicals like Acebutolol, Ambroxol, Sorafenib and so on.4-Aminophenol is used as a dye for textiles, hair, furs and feathers, and is also used as a developing agent in photography for creating black and white images. It acts as a corrosion inhibitor in paints and as anti-corrosive lubricating agent in 2-cycle engines. It is also used as a wood stain, giving rose-like colour to timber. p-Aminophenol is one of key ingredients for synthesis of rubber antioxidants. Moreover, it is often used as a reagent for analysing metals like Copper, Magnesium, Vanadium and Gold, compounds like Nitrites and Cyanates, and antioxidants.
정의
ChEBI: 4-aminophenol is an amino phenol (one of the three possible isomers) which has the single amino substituent located para to the phenolic -OH group. It has a role as a metabolite and an allergen.일반 설명
P-aminophenol appears as white or reddish-yellow crystals or light brown powder. Turns violet when exposed to light. (NTP, 1992)공기와 물의 반응
Insoluble in water.반응 프로필
Heat (decomposition forming HCN, nitrous vapors, CO); water (CO2); reacts violently with acids, bases, alcohols and amines causing fire and explosion hazards [Handling Chemicals Safely 1980 p. 647].건강위험
p-Aminophenol is of moderately low toxicity but has caused dermal sensitization and kidney injury; the potential for producing methemoglobin is of relatively minor importance.The oral LD50 in rats was 671 mg/kg.1 Effects included central nervous system depression. A solution of 2.5% applied to abraded skin of rabbits was a mild irritant.1 p- Aminophenol caused dermal sensitization in guinea pigs, and skin sensitization has been reported in humans.2,3 The dermal LD50 in rabbits was greater than 8 g/kg, which strongly suggests that absorption through the skin is minimal.4 Single nonlethal acute doses in rats produced proximal renal tubular necrosis of the pars recta.
화재위험
Flash point data are not available for 4-Aminophenol. 4-Aminophenol is probably combustible.색상 색인 번호
This hair dye is frequently implicated in contact dermatitis in hairdressers, customers, or people sensitized to para-phenylenediamine, by the way of “blackhenna” temporary tattoos.Safety Profile
Poison by ingestion, subcutaneous, and intraperitoneal routes. An experimental teratogen. Other experimental reproductive effects. An allergen and skin and eye irritant. Mutation data reported. Can cause contact dermatitis, bronchial asthma, and methemoglobinemia with cyanosis. When heated to decomposition it emits toxic fumes of NOx,.잠재적 노출
Workers may be exposed to oAminophenol during its use as a chemical intermediate; in the manufacture of azo and sulfur dyes; and in the photographic industry. There is potential for consumer exposure to o-Aminophenol because of its use in dyeing hair, fur, and leather. The compound is a constituent of 75 registered cosmetic products suggesting the potential for widespread consumer exposure. p-Aminophenol is used mainly as a dye, dye intermediate and as a photographic developer; and in small quantities in analgesic drug preparation. Consumer exposure to p-aminophenol may occur from use as a hairdye or as a component in cosmetic preparations. m-Aminophenol is used mainly as a dye intermediate.Solubility in organics
Very soluble in dimethylsulfoxide Soluble in acetonitrile, ethyl acetate, and acetone Slightly soluble in toluene, diethyl ether, and ethanol Negligible solubility in benzene and chloroform운송 방법
UN2512 Aminophenols (o-; m-; p-), Hazard Class: 6.1; Labels: 6.1-Poisonous materialsPurification Methods
Crystallise it from EtOH, then water, excluding oxygen. It sublimes at 110o/0.3mm. It has been purified by chromatography on alumina with a 1:4 (v/v) mixture of absolute EtOH/*benzene as eluent. [Beilstein 13 IV 1014.]비 호환성
These phenol/cresol materials can react with oxidizers; reaction may be violent. Incompatible with strong reducing substances such as alkali metals, hydrides, nitrides, and sulfides. Flammable gas (H2) may be generated, and the heat of the reaction may cause the gas to ignite and explode. Heat may be generated by the acidbase reaction with bases; such heating may initiate polymerization of the organic compound. Reacts with boranes, alkalies, aliphatic amines, amides, nitric acid, sulfuric acid. Phenols are sulfonated very readily (e.g., by concentrated sulfuric acid at room temperature). These reactions generate heat. Phenols are also nitrated very rapidly, even by dilute nitric acid and can explode when heated. Many phenols form metal salts that may be detonated by mild shock.폐기물 처리
Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed.4-아미노페놀 준비 용품 및 원자재
원자재
발연황산
나이트로페놀
Fine chemicals
4-NITROCATECHOL
N-Phenylhydroxylamine
4-니트로페놀소다염(2수화물)
염산
p-니트로페놀
철분
황산
산성아황산나트륨
준비 용품
Sulphur Blue CV
4-(P-하이드록시아닐리노)퀴나졸린
p-펜네티딘
INDOPHENOL ACETATE
아세트아미노펜
IMMEDIAL BRILLIANT GREEN GB
DIAMINE GREEN B
Sulphur Red 6
2-Hydroxy-N-(4-hydroxyphenyl)-benzamide
THIFLUZAMIDE
N-(1,3-다이메틸뷰틸-N'-페닐-p-페닐렌디아민)
Sulphur Black 6
Roxarsone
메톨
Sulfur Red Brown B3R
4-(4-클로로-벤질록시)-페닐아민
클로피브레이트
7-CHLORO-10-(4-HYDROXYANILINO)-2-METHOXY BENZO(B)-1,5-NAPHTHY RIDINE
Sulphur Dark Blue 3R
6-히드록시퀴노린
4-요오드페놀
ACID YELLOW 76 (C.I. 18850)
N-(4-하이드록시페닐)-2-나프틸아민,97
4-Iodophenoxyacetic acid
에틸렌글리콜모노부틸에테르
4-아미노페놀 공급 업체
글로벌( 701)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Taizhou Suze Chemical Materials Co.,Ltd. | +86-0523-86392777 +86-19825580222 |
nick.miao@suzechem.com | China | 23 | 58 |
Guangzhou Tosun Pharmaceutical Limited | +8618922120635 |
sales@toref-standards.com | China | 1000 | 58 |
Hebei Guanlang Biotechnology Co,.LTD | +8619930503252 |
daisy@crovellbio.com | China | 5828 | 58 |
Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 |
qinhe02@xaltbio.com | China | 1000 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29798 | 60 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21668 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32760 | 60 |
Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +86-18949832763 |
info@tnjchem.com | China | 2989 | 55 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29894 | 58 |
NINGBO INNO PHARMCHEM CO., LTD. | 13867897135 |
sales@nbinno.com | CHINA | 925 | 58 |