FILGRASTIM
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FILGRASTIM 속성
- 저장 조건
- -70°C
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
HS 번호 | 3002905150 | ||
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유해 물질 데이터 | 121181-53-1(Hazardous Substances Data) | ||
독성 | LD50 oral in rat: > 3mg/kg |
그림문자(GHS): | |||||||||||||||
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신호 어: | Warning | ||||||||||||||
유해·위험 문구: |
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예방조치문구: |
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FILGRASTIM C화학적 특성, 용도, 생산
개요
Filgrastim is a recombinant human granulocyte colony stimulating factor (G-CSF) indicated as an adjunct to cancer chemotherapy for patients with non-myeloid malignancies. It reduces the duration of chemotherapy-induced neutropenia by forcing immature leucocytes to differentiate into neutrophils, thereby decreasing the incidence and length of infections.Bone pain is the most significant side effect.Chugai launched the second G-CSF, lenograstim, in December 1991. Other potential uses include bone marrow transplants, myelodysplastic syndromes and febrilelchronic neutropenia.화학적 성질
Clear, colourless or slightly yellowish liquid용도
Filgrastim is a human granulocyte colony stimulating factor (G-CSF) used to treat neutropenia.Indications
Filgrastim (Neupogen) is a human recombinant granulocyte colony–stimulating factor (rG-CSF) produced using recombinant DNA technology. It acts on precursor hematopoietic cells in the bone marrow by binding to specific receptors that stimulate cellular proliferation and differentiation into neutrophils. It also enhances some neutrophil functions, including phagocytosis and antibody-dependent killing.Clinical Use
Filgrastim, G-CSF, Neupogen, stimulates the proliferation ofgranulocytes (especially neutrophils) by mobilizinghematopoietic stem cells in the bone marrow. The native protein is glycosylated.Filgrastim selectively stimulates proliferation and differentiationof neutrophil precursors in the bone marrow. Thisleads to the release of mature neutrophils into the circulationfrom the bone marrow. Filgrastim also affects mature neutrophilsby enhancing phagocytic activity, priming the cellularmetabolic pathways associated with the respiratoryburst, enhancing antibody-dependent killing, and increasingthe expression of some functions associated with cell surfaceantigens.In patients receiving chemotherapy with drugs such ascyclophosphamide, doxorubicin, and etoposide, the incidenceof neutropenia accompanied by fever is rather high.Administration of G-CSF reduces the time of neutrophilrecovery and duration of fever in adults with acute myelogenousleukemia. The number of infections, days thatantibiotics are required, and duration of hospitalization arealso reduced.
부작용
The drug is generally well tolerated, with the major adverse reaction being mild to moderate bone pain secondary to stimulation of bone marrow proliferation.FILGRASTIM 준비 용품 및 원자재
원자재
준비 용품
FILGRASTIM 공급 업체
글로벌( 41)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
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Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21665 | 55 |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 |
1026@dideu.com | China | 23699 | 58 |
AFINE CHEMICALS LIMITED | +86-0571-85134551 |
sales@afinechem.com | China | 15392 | 58 |
GIHI CHEMICALS CO.,LIMITED | +8618058761490 |
info@gihichemicals.com | China | 50003 | 58 |
Chemwill Asia Co.,Ltd. | 86-21-51086038 |
chemwill_asia@126.com | CHINA | 23931 | 58 |
Hangzhou Sage Chemical Co., Ltd. | +86057186818502 13588463833 |
info@sagechem.com | China | 10269 | 58 |
Beijing HuaMeiHuLiBiological Chemical | 010-56205725 |
waley188@sohu.com | China | 12338 | 58 |
Chizhou Kailong Import and Export Trade Co., Ltd. | |
xg01_gj@163.com | China | 9503 | 50 |
Shanghai Synchem Pharma Co., ltd | 21-619849051-1 18521059765 |
synchempharma@aliyun.com | China | 6463 | 55 |
Beijing Solarbio Science & Tecnology Co., Ltd. | 010-50973186 4009686088 |
3193328036@qq.com | China | 18352 | 68 |
FILGRASTIM 관련 검색:
디스프로슘 트리(2,2,6,6-테트라메틸-3,5-헵탄디오네이트) 코발트(II) 아세틸아세토네이트 하이드레이트 아세틸아세톤산 구리 아세틸아세토산 제2철 알루미늄 아세틸아세토네이트 실버 아세틸아세토네이트
Ethyl isocyanoacetate
PHENYLSELENOL
N-BUTYLISOCYANIDE
TERT-BUTYL ISOCYANIDE
1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE
SALCOMINE
DICHLORO(ETHYLENEDIAMINE)PLATINUM(II)
TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III)
METHYL ISOCYANOACETATE
Tosylmethyl isocyanide
Tris(2,4-pentanedionato)chroMiuM(III)
Benzyl isocyanide