프로카바진 수화염화물
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프로카바진 수화염화물 속성
- 녹는점
- 223°C
- 밀도
- 8.3 g/cm3
- 저장 조건
- Inert atmosphere,2-8°C
- 용해도
- DMSO: ≥18mg/mL
- 물리적 상태
- 가루
- 색상
- 흰색에서 황갈색까지
- 수용성
- 21.5&C에서 >=10g/100mL
- Merck
- 14,7758
- BCS Class
- 3/1
- InChI
- 1S/C12H19N3O.ClH/c1-9(2)15-12(16)11-6-4-10(5-7-11)8-14-13-3;/h4-7,9,13-14H,8H2,1-3H3,(H,15,16);1H
- InChIKey
- DERJYEZSLHIUKF-UHFFFAOYSA-N
- SMILES
- Cl.CNNCc1ccc(cc1)C(=O)NC(C)C
- CAS 데이터베이스
- 366-70-1(CAS DataBase Reference)
- IARC
- 2A (Vol. 26, Sup 7) 1987
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | T | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 45-61-22-68 | ||
| 안전지침서 | 53-36/37-45 | ||
| WGK 독일 | 3 | ||
| RTECS 번호 | XS4725000 | ||
| HS 번호 | 2928002500 | ||
| 스토리지 클래스 | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
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| Hazard Classifications | Acute Tox. 4 Oral Carc. 1B Muta. 2 Repr. 1A |
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| 독성 | LD50 orally in rats: 785 ±34 mg/kg (Goldenthal) |
프로카바진 수화염화물 C화학적 특성, 용도, 생산
화학적 성질
Crystalline Solid용도
Procarbazine hydrochloride USP is used to traet Hodgkin’s disease; non-Hodgkin’s lymphomas; lung cancer.정의
ChEBI: A hydrochloride obtained by combining procarbazine with one equivalent of hydrochloric acid. An antineoplastic chemotherapy drug used for treatment of Hodgkin's lymphoma. Metabolism yields azo-procarbazine and hydrogen peroxide, which results in the breaki g of DNA strands.일반 설명
White to pale yellow crystalline powder with a slight odor. Acid to litmus.공기와 물의 반응
In the presence of moisture or in aqueous solution undergoes oxidation by atmospheric oxygen. Water soluble.반응 프로필
Procarbazine hydrochloride is very sensitive to light. Stability is highest in aqueous acid and decreases with increasing pH. Degrades rapidly in alcoholic media and more slowly in aqueous media .화재위험
Flash point data for Procarbazine hydrochloride are not available; however, Procarbazine hydrochloride is probably combustible.Safety Profile
Confirmed carcinogen with experimental carcinogenic, neoplastigenic, tumorigenic, and teratogenic data. Poison by an unspecified route. Moderately toxic by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and HCl. Used as a chemotherapeutic agent.잠재적 노출
Procarbazine is available in capsule form. The primary use of this drug is as an antineoplastic agent in the treatment of advanced Hodgkin’s disease, and oat-cell carcinoma of the lung. The hydrochloride com- pound is used in treatment. The FDA approved use of pro- carbazine hydrochloride in 1969 and indicated that the drug should be used as an adjunct to standard therapy. Possible exposure occurs during manufacture of the drug and direct exposure during its subsequent administration to patients. Some of the metabolites of procarbazine hydrochloride are both carcinostatic and carcinogenic.운송 방법
UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.비 호환성
Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides.폐기물 처리
It is inappropriate and possibly dangerous to the environment to dispose of expired or waste drugs and pharmaceuticals by flushing them down the toilet or discarding them to the trash. Household quantities of expired or waste pharmaceuticals may be mixed with wet cat litter or coffee grounds, double-bagged in plastic, discard in trash. Larger quanti- ties shall carefully take into consideration applicable DEA, EPA, and FDA regulations. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator.프로카바진 수화염화물 준비 용품 및 원자재
원자재
준비 용품
프로카바진 수화염화물 공급 업체
글로벌( 217)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 |
Sibel@chuanghaibio.com | China | 8738 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-81138252 +86-173 9270 1263 |
1057@dideu.com | China | 3958 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-86-13131129325 +8613131129325 |
sales1@chuanghaibio.com | China | 5220 | 58 |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 |
deasea125996@gmail.com | China | 2472 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21585 | 55 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 |
product@chemlin.com.cn | CHINA | 3009 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29812 | 58 |
| BOC Sciences | +1-631-485-4226 |
inquiry@bocsci.com | United States | 19936 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49979 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 |
marketing@targetmol.com | United States | 32466 | 58 |