L-Iduronic acid

L-Iduronic acid C화학적 특성, 용도, 생산

개요

L-Iduronic acid (IdoA) is the major uronic acid component of the glycosaminoglycans (GAGs) dermatan sulfate, and heparin. It is also present in heparan sulfate although here in a minor amount relative to its carbon-5 epimer glucuronic acid.
IdoA is a hexapyranose sugar. Most hexapyranoses are stable in one of two chair conformations ¹C₄ or ⁴C₁. L-iduronate is different and adopts more than one solution conformation, with an equilibrium existing between three low-energy conformers. These are the ¹C₄ and ⁴C₁ chair forms and an additional ²S₀ skew-boat conformation.
IdoA may be modified by the addition of an O-sulfate group at carbon position 2 to form 2-O-sulfo-L-iduronic acid (IdoA2S). In 2000, LK Hallak described the importance of this sugar in respiratory syncytial virus infection. Dermatan sulfate and heparan sulfate were the only GAGs containing IdoA, and they were the only ones that inhibited RSV infection in cell culture. When internally positioned within an oligosaccharide, the ¹C₄ and ²S₀ conformations (shown below for IdoA2S) predominate. Proton NMR spectroscopy can be used to track changes in the balance of this equilibrium.

L-Iduronic acid 준비 용품 및 원자재

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준비 용품

L-Iduronic acid 공급 업체

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