살구십자

살구십자
살구십자 구조식 이미지
카스 번호:
197904-84-0
한글명:
살구십자
동의어(한글):
살구십자
상품명:
Apricoxib
동의어(영문):
TG 01;CS 706;R 109339;Apricoxib;Benzenesulfonamide, 4-[2-(4-ethoxyphenyl)-4-methyl-1H-pyrrol-1-yl]-
CBNumber:
CB82627333
분자식:
C19H20N2O3S
포뮬러 무게:
356.44
MOL 파일:
197904-84-0.mol

살구십자 속성

녹는점
148-151°C
끓는 점
555.3±60.0 °C(Predicted)
밀도
1.24±0.1 g/cm3(Predicted)
저장 조건
Refrigerator
용해도
클로로포름(약간 용해됨), 메탄올(약간 용해됨)
물리적 상태
고체
물리적 상태
단단한 모양
산도 계수 (pKa)
9.77±0.10(Predicted)
색상
노란색

안전

살구십자 C화학적 특성, 용도, 생산

용도

Apricoxib, is an orally active, selective COX-2 inhibitor, used as as an analgesic and anti-inflammatory agent, and also has anticancer potential, since COX-2 inhibition can reduce tumor growth and augment therapy.

효소 저해제

This oral COX-2 inhibitor (FW = 356.44 g/mol; CAS 162011-90-7), also named CS-706 and 4-[2- (4-ethoxyphenyl) -4-methyl-1H-pyrrol-1-yl]- benzene sulfonamide, targets Cyclooxygenase-2, which is over- expressed in advanced stage non-small-cell lung cancer (NSCLC), possibly as a result of elevated levels of COX-2-dependent prostaglandin E2 (PGE2). That said, a randomized, double-blind, placebo-controlled, multicenter phase II study found little evidence of efficacy of apricoxib in combination with either docetaxel or pemetrexed in patients with biomarker-selected NSCLC. See also Rofecoxib

살구십자 준비 용품 및 원자재

원자재

준비 용품


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