Dobutamine hydrochloride, a dopamine derivative, is a selective β1-adrenergic agonist. It is a sympathomimetic agent with inotropic action (changes strength of muscle contraction) on the heart. However, it may have some α and β2-agonist properties as well.The active substance strengthens the contraction power of the heart, increases the stroke volume and thus the blood circulation of the organs. It is used for the treatment of acute heart failure and for cardiac stress tests.
화학적 성질
Dobutamine hydrochloride occurs as a white to off-white crystalline powder, which is sparingly soluble in water and in alcohol. Dobutamine has a pKa of 9.4.
용도
Dobutamine Hydrochloride is a sympathomimetic drug used to treat heart failure by inhibiting β1 receptors in the sympathetic nervous system. Cardiotonic.
정의
ChEBI: The hydrochloride salt of dobutamine. A beta1-adrenergic receptor agonist that has cardiac stimulant action without evoking vasoconstriction or tachycardia, it is used to increase the contractility of the heart in the m
nagement of acute heart failure.
생물학적 활성
β 1 - and β 2 -adrenoceptor agonist with some action at the α 1 -adrenoceptor.
