Cromoglicic acid
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Cromoglicic acid 속성
- 녹는점
- 241-242°C
- 끓는 점
- 752.3±60.0 °C(Predicted)
- 밀도
- 1.623
- 저장 조건
- 2-8°C
- 산도 계수 (pKa)
- pKa 2.0 (Uncertain)
- CAS 데이터베이스
- 16110-51-3(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xi | ||
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위험 카페고리 넘버 | 36/37/38 | ||
안전지침서 | 26-36 | ||
WGK 독일 | 2 | ||
RTECS 번호 | DJ2380000 | ||
유해 물질 데이터 | 16110-51-3(Hazardous Substances Data) | ||
독성 | rat,LD50,oral,> 2150mg/kg (2150mg/kg),United States Patent Document. Vol. #4407810, |
그림문자(GHS): | |||||||||||||||||||||||||||||
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신호 어: | Warning | ||||||||||||||||||||||||||||
유해·위험 문구: |
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예방조치문구: |
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Cromoglicic acid C화학적 특성, 용도, 생산
개요
Cromolyn is a synthetic analog of the plant extract khellin that was first developed in the late 1960s and introduced into clinical practice the following decade. It is continued to be used widely in the treatment of allergic rhinitis, asthma, mastocytosis, and conjunctivitis. It has an outstanding safety profile and can be readily obtained without prescription in many countries.용도
Anti Asthamatic정의
ChEBI: A dicarboxylic acid that is the bis-chromone derivative of glycerol. It is effective as a mast cell stabilizer.일반 설명
Solid.공기와 물의 반응
Water soluble.반응 프로필
Carboxylic acids donate hydrogen ions if a base is present to accept them. They react in this way with all bases, both organic (for example, the amines) and inorganic. Their reactions with bases, called "neutralizations", are accompanied by the evolution of substantial amounts of heat. Neutralization between an acid and a base produces water plus a salt. Carboxylic acids in aqueous solution and liquid or molten carboxylic acids can react with active metals to form gaseous hydrogen and a metal salt. Such reactions occur in principle for solid carboxylic acids as well, but are slow if the solid acid remains dry. Even "insoluble" carboxylic acids may absorb enough water from the air and dissolve sufficiently in Cromoglicic acid to corrode or dissolve iron, steel, and aluminum parts and containers. Carboxylic acids, especially in aqueous solution, also react with sulfites, nitrites, thiosulfates (to give H2S and SO3), dithionites (SO2), to generate flammable and/or toxic gases and heat.화재위험
Flash point data for Cromoglicic acid are not available. Cromoglicic acid is probably combustible.Mechanism of action
Cromolyn stabilizes the membranes of mast cells, stopping the release of allergy mediators and suppressing activation of eosinophiles, neutrophilis, thrombocytes, and macrophages, which take part in the formation of bronchospasms. Cromylyn differs from the majority of medications taken for obstructive diseases of the respiratory tract in that it is used only as a preventative agent.Clinical Use
Cromolyn generally is used prophylactically for bronchial asthma (as an inhaled powder), for prevention of exercise-induced bronchospasm, and for seasonal and perennial allergic rhinitis (nasal solution). Topically, it also is used as eye drops for allergic conjunctivitis and keratitis. In the management of asthmatic conditions, it is administered using a power-operated nebulizer. The bioavailability is very low with oral administration because of poor absorption. By inhalation, the powder is irritating to some patients. After inhalation, much less than 10% of the dose reaches the systemic circulation. An oral dosage form is used for mastocytosis.환경귀착
The major prophylactic effect of cromolyn is centered on inhibition of the degranulation of pulmonary mast cells causing a reduction in histamine release, reduced leukotriene production, and inhibition of release of inflammatory mediators from several cell types.Cromoglicic acid 준비 용품 및 원자재
원자재
준비 용품
Cromoglicic acid 공급 업체
글로벌( 120)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
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Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 20290 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21663 | 55 |
Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 |
figo.gao@foxmail.com | China | 8348 | 58 |
Alchem Pharmtech,Inc. | 8485655694 |
sales@alchempharmtech.com | United States | 63711 | 58 |
Career Henan Chemica Co | +86-0371-86658258 +8613203830695 |
laboratory@coreychem.com | China | 30250 | 58 |
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 |
sales@hzclap.com | CHINA | 6313 | 58 |
ANHUI WITOP BIOTECH CO., LTD | +8615255079626 |
eric@witopchemical.com | China | 23555 | 58 |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 |
1026@dideu.com | China | 23499 | 58 |
Finetech Industry Limited | +86-27-87465837 +8618971612321 |
info@finetechnology-ind.com | China | 9640 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 |
support@targetmol.com | United States | 19973 | 58 |
Cromoglicic acid 관련 검색:
스테아르산 아세트산 글리세릴 모노스테아레이트 시트르산 엽산
EPA
Fmoc-D-Trp(Boc)-OH
Ascoric Acid
2',6'-Dihydroxyacetophenone
Cromolyn Disodium Salt
1,3-Bis(2-hydroxyethoxy)benzene
Diethyl cromoglycate
1,3-Diphenoxy-2-propanol
2,2’-(1,3-Propanediyldioxy)bisbenzaldehyde
5-HYDROXY-4-OXO-4H-CHROMENE-2-CARBOXYLIC ACID
N 556
ETHYL CROMOGLICATE
CARBOXYLIC ACID