γ-사이클로덱스트린
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γ-사이클로덱스트린 속성
- 녹는점
- ≥300 °C
- 끓는 점
- 845.2°C (rough estimate)
- 알파
- [α]D25 +174~+179° (c=1, H2O) (After Drying)
- 밀도
- 1.2064 (rough estimate)
- 굴절률
- 1.7500 (estimate)
- 인화점
- 450℃
- 저장 조건
- room temp
- 용해도
- 1M NaOH: 25mg/mL, 투명하거나 약간 흐릿할 수 있음
- 물리적 상태
- 가루
- 산도 계수 (pKa)
- 11.68±0.70(Predicted)
- 색상
- 하얀색
- 냄새
- 100.00%. 냄새 없는
- optical activity
- [α]/D 174.0 to 180.0°
- 수용성
- 232g/L(25℃)
- 최대 파장(λmax)
- λ: 420 nm Amax: ≤0.20
- Merck
- 14,2718
- BRN
- 5725162
- 안정성
- 흡습성
- InChIKey
- GDSRMADSINPKSL-HSEONFRVSA-N
- LogP
- -12.02
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xi | ||
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위험 카페고리 넘버 | 36/37/38 | ||
안전지침서 | 26-36-24/25-22 | ||
WGK 독일 | 2 | ||
RTECS 번호 | GU2293080 | ||
F 고인화성물질 | 3 | ||
HS 번호 | 29400000 | ||
기존화학 물질 | 2013-3-5585 |
그림문자(GHS): | ||||||||||||||||||||||
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신호 어: | Warning | |||||||||||||||||||||
유해·위험 문구: |
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예방조치문구: |
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γ-사이클로덱스트린 C화학적 특성, 용도, 생산
화학적 성질
White powder or crystal용도
A molecule used to solublize non-polar molecules such a cholesterol for use in cell culture.생산 방법
Cyclodextrins are manufactured by the enzymatic degradation of starch using specialized bacteria. For example, β-cyclodextrin is produced by the action of the enzyme cyclodextrin glucosyltransferase upon starch or a starch hydrolysate. An organic solvent is used to direct the reaction that produces β-cyclodextrin, and to prevent the growth of microorganisms during the enzymatic reaction. The insoluble complex of β-cyclodextrin and organic solvent is separated from the noncyclic starch, and the organic solvent is removed in vacuo so that less than 1 ppm of solvent remains in the β-cyclodextrin. The β-cyclodextrin is then carbon treated and crystallized from water, dried, and collected.일반 설명
Cyclodextrins belongs to the family of cyclic α-1,4-glucans and is made of glucose units. This molecule has a shape of a hollow cone. It possesses a hydrophilic external and hydrophobic internal surface, because of which cyclodextrins can form inclusion complexes. γ-Cyclodextrin is extensively used in food and pharmaceutical industries. Cyclodextrins are obtained by the enzymatic conversion of starch/starch derivatives by cyclodextrin glycosyltransferase.Pharmaceutical Applications
Cyclodextrins are ‘bucketlike’ or ‘conelike’ toroid molecules, with a rigid structure and a central cavity, the size of which varies according to the cyclodextrin type. The internal surface of the cavity is hydrophobic and the outside of the torus is hydrophilic; this is due to the arrangement of hydroxyl groups within the molecule. This arrangement permits the cyclodextrin to accommodate a guest molecule within the cavity, forming an inclusion complex.Cyclodextrins may be used to form inclusion complexes with a variety of drug molecules, resulting primarily in improvements to dissolution and bioavailability owing to enhanced solubility and improved chemical and physical stability.
Cyclodextrin inclusion complexes have also been used to mask the unpleasant taste of active materials and to convert a liquid substance into a solid material. γ-cyclodextrin has the largest cavity and can be used to form inclusion complexes with large molecules;it has low toxicity and enhanced water solubility.
In parenteral formulations, cyclodextrins have been used to produce stable and soluble preparations of drugs that would otherwise have been formulated using a nonaqueous solvent.
In eye drop formulations, cyclodextrins form water-soluble complexes with lipophilic drugs such as corticosteroids. They have been shown to increase the water solubility of the drug; to enhance drug absorption into the eye; to improve aqueous stability; and to reduce local irritation.
Cyclodextrins have also been used in the formulation of solutions,suppositories, and cosmetics.
Safety
Cyclodextrins are starch derivatives and are mainly used in oral and parenteral pharmaceutical formulations. They are also used in topical and ophthalmic formulations.Cyclodextrins are also used in cosmetics and food products, and are generally regarded as essentially nontoxic and nonirritant materials. However, when administered parenterally, β-cyclodextrin is not metabolized but accumulates in the kidneys as insoluble cholesterol complexes, resulting in severe nephrotoxicity.
Cyclodextrin administered orally is metabolized by microflora in the colon, forming the metabolites maltodextrin, maltose, and glucose; these are themselves further metabolized before being finally excreted as carbon dioxide and water. Although a study published in 1957 suggested that orally administered cyclodextrins were highly toxic, more recent animal toxicity studies in rats and dogs have shown this not to be the case, and cyclodextrins are now approved for use in food products and orally administered pharmaceuticals in a number of countries.
Cyclodextrins are not irritant to the skin and eyes, or upon inhalation. There is also no evidence to suggest that cyclodextrins are mutagenic or teratogenic.
γ-Cyclodextrin
LD50 (rat, IP): 4.6 g/kg
LD50 (rat ,IV): 4.0 g/kg
LD50 (rat, oral): 8.0 g/kg
저장
Cyclodextrins should be stored in a tightly sealed container, in a cool, dry place.Cyclodextrins are stable in the solid state if protected from high humidity.Regulatory Status
Included in the FDA Inactive Ingredients Database: α-cyclodextrin (injection preparations); β-cyclodextrin (oral tablets, topical gels); γ-cyclodextrin (IV injections).Included in the Canadian List of Acceptable Non-medicinal Ingredients (stabilizing agent; solubilizing agent ); and in oral and rectal pharmaceutical formulations licensed in Europe, Japan, and the USA.
γ-사이클로덱스트린 준비 용품 및 원자재
원자재
말토덱스트린
Ring compound
덱스트린
Maltodextrin
N-데칸
수퍼옥사이드 디스무타제
Reverse osm
Chromatography
사이클로덱스트린
알파-시클로덱스트린
MALTOOCTAOSE
준비 용품
γ-사이클로덱스트린 공급 업체
글로벌( 434)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
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Henan Allgreen Chemical Co.,LTD | +86-37155567971 +86-13633837469 |
info@allgreenchem.com | China | 5986 | 58 |
Wuhan Fortuna Chemical Co., Ltd | +86-027-59207850 |
info@fortunachem.com | China | 5987 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 |
sales@hbmojin.com | China | 12495 | 58 |
Hebei Yanxi Chemical Co., Ltd. | +8617531190177 |
peter@yan-xi.com | China | 5873 | 58 |
Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 |
sales1@chuanghaibio.com | China | 5895 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 20291 | 58 |
Shandong Juchuang Chemical Co., LTD | +undefined15030412209 |
admin@juchuangchem.com | China | 387 | 58 |
airuikechemical co., ltd. | +undefined86-15315557071 |
sales02@sdzhonghuimaterial.com | China | 983 | 58 |
Hebei Saisier Technology Co., LTD | +86-18400010335 +86-18034520335 |
admin@hbsaisier.cn | China | 1009 | 58 |
Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 |
admin@zlchemi.com | China | 3002 | 58 |
γ-사이클로덱스트린 관련 검색:
감마-아미노-N-부티르 산 메틸-베타-싸이클로덱스트린 덱스트린
beta-Cyclodextrin hydrate
CYCLODEXTRIN
2-Hydroxypropyl-β-cyclodextrin
β-Cyclodextrin
Polyglutamic acid
OCTAKIS-6-BROMO-6-DEOXY-GAMMA-CYCLODEXTRIN
Sugammadex sodium Impurity 37
Sugammadex sodium Impurity 39
Sugammadex Sodium Impurity 36
Sugammadex sodium Impurity 40
Sugammadex Impurity 4 (Monobromo Sugammadex Sodium)
Sugammadex Sodium Impurity 35
Sugammadex Sodium Impurity 33
GAMMA-CYCLODEXTRIN HYDRATE
(2-Hydroxypropyl)-γ-cyclodextrin