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59-05-2(Methotrexate) Product Description

Methotrexate Structure59-05-2
CAS No.59-05-2
Chemical Name:Methotrexate
CBNumber:CB2739302
Molecular Formula:C20H22N8O5
Formula Weight:454.45
MOL File:Mol file
Methotrexate Synonyms:
METHOTREXATEFORINJECTION
METHOTREXATE(N-(4-(((2,4-DIAMINO-6-PTERIDINYL)METHYLAMINO)BENZOYL)-L-GLUTAMICACID)
4-Amino-N10-methylfolic acid
Glutamic acid, N-[p-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, L-(+)- (8CI)
L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]- (9CI)
L-Methotrexate
Methotrexat-Ebewe
METHOTREXATEC

Methotrexate Property

Melting point: 195°C
Boiling point: 561.26°C (rough estimate)
alpha  +17～+24°(D/20℃)(c=1,Na2CO3 soln.)(calculated on the dehydrous basis)
Density  1.4080 (rough estimate)
refractive index  1.6910 (estimate)
Flash point: 11℃
storage temp.  Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility  H2O: insoluble
form  powder
pka pKa 3.04/4.99(H2O,t =25,I=0.0025) (Uncertain)
color  Light yellow to yellow
Water Solubility  Insoluble. <0.1 g/100 mL at 19 ºC
Sensitive  Light Sensitive & Hygroscopic
Merck  14,5985
BRN  70669
BCS Class 3
Stability: Stable, but light sensitive and hygroscopic. Incompatible with strong acids, strong oxidizing agents. Store at -15C or below.
InChIKey FBOZXECLQNJBKD-ZDUSSCGKSA-N
CAS DataBase Reference 59-05-2(CAS DataBase Reference)
NIST Chemistry Reference Methotrexate(59-05-2)
IARC 3 (Vol. 26, Sup 7) 1987
EPA Substance Registry System Methotrexate (59-05-2)

Safety

Hazard Codes : T,F
Risk Statements : 61-25-36/38-46-39/23/24/25-23/24/25-11
Safety Statements : 53-26-36/37-45-36/37/39-36-16
RIDADR : UN 2811 6.1/PG 3
WGK Germany : 3
RTECS : MA1225000
F : 3-8-10
TSCA : Yes
HazardClass : 6.1(b)
PackingGroup : III
HS Code : 29335995
Hazardous Substances Data: 59-05-2(Hazardous Substances Data)
Toxicity: LD50 oral in rat: 135mg/kg

MSDS

(+)-4-Amino-10-methylfolic acid MSDS(+)-4-Amino-10-methylfolic acid

Methotrexate Suppliers

Global( 726)Suppliers     
SupplierTelEmailCountryProdListAdvantage
Suzhou Surui Pharmaceutical Chemical Co., Ltd 0512-680861963228574886@qq.comChina 11 58
Guangzhou Isun Pharmaceutical Co., Ltd 020-39119399isunpharm@qq.comChina 4428 55
Zhenjiang Hongyu Biotechnology Co., Ltd  19708301@qq.comChina 31 58
Panjin Jiahe Shengshi Pharmaceutical Technology Co., Ltd 18504053675sale@jhssw.comChina 52 58
FarmaSino Pharmaceuticals (Jiangsu) Co.,Ltd  mqm@farmasino.comChina 193 58
HUBEI MICRO PHARMACEUTICAL  info@micropharm.cnChina 66 58
XI'AN VEDA CHEMICAL CO.,LTD 029-88665278sherryliu@vedachem.comChina 47 58
Wuhan Hongde Yuexin Pharmaceutical Technology Co., Ltd 02783850058whhdyxchem027@sina.comChina 2730 58
59-05-2(Methotrexate) Related Search:
METHOTREXATEFORINJECTION METHOTREXATE(N-(4-(((2,4-DIAMINO-6-PTERIDINYL)METHYLAMINO)BENZOYL)-L-GLUTAMICACID) 4-Amino-N10-methylfolic acid Glutamic acid, N-[p-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, L-(+)- (8CI) L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]- (9CI) L-Methotrexate Methotrexat-Ebewe METHOTREXATEC methotrexate，MTX (+)-Amethopterin L-(+)-AMETHOPTERIN HYDRATE (METHOTREXATE) (+)-Amethopterin, 4-Amino-10-methylfolic acid, 4-Amino-N10-methylpteroyl-L-glutamic acid, Antifolan, Methylaminopterin, MTX 4-Amino-4-deoxy-N(10)-methylpteroylglutamate 4-Amino-4-deoxy-N(10)-methylpteroylglutamic acid Methotrexate (500 mg)I1D1080.999mg/mg(an) Methotrexate (500 mg) METHOTREXATE(P)(CALL) (S)-2-(4-(((2,4-DiaMinopteridin-6-yl)Methyl)-(Methyl)aMino)benzaMido)pentanedioic acid, 95+% Methotrexate solution BROMOCRESCOL PURPLE NA SALT HIGH PURITY L-4-Amino-N10-methylpteroylglutamic acid hydrate METHOTREXATE METHYLAMINOPTERIN METHYLAMINOPTERINE ANTIFOLAN L-(+)-AMETHOPTERIN 4-AMINO-N 10-METHYLPTEROYL-L-GLUTAMIC ACID 4-AMINO-10-METHYLPTEROYLGLUTAMIC ACID (+)-4-AMINO-10-METHYLFOLIC ACID 4-AMINO-10-METHYLFOLIC ACID (S)-2-(4-(((2,4-DiaMinopteridin-6-yl)Methyl)(Methyl)aMino)benzaMido)pentanedioic acid Methotrexate  N-[4-[[(2,4-DiaMino-6-pteridinyl)Methyl]MethylaMino]benzoyl]- n-(p-(((2,4-diamino-6-pteridinyl)methyl)methylamino)benzoyl)-l-glutamic acid METHOTREXATE USP 24 (+)-Amethopterin, 4-Amino-10-methylpteroylglutamic Acid Methotrexate API L-(+)-AMethopterin Dihydrate, 99% (see Methotrexate) METHOTREXATE HYDRATE CELL/INSECT CELL*CU LTURE TESTE MethotrexateGmp/Ctdep5/Usp28 MethotrexateGmp/Ctd Methotrexate Disodium 15475-56-6 / Base N-[4-[[(2,4-DIAMINO-6-PTERIDINYL)METHYL]METHYLAMINO]BENZOYL]-L-GLUTAMIC ACID 4-amino-4-deoxy-n(sup10)-methylpteroylglutamate 4-Amino-4-deoxy-N(sup10)-methylpteroylglutamic acid 4-amino-4-deoxy-n(sup10)-methylpteroylglutamicacid 4-amino-n(10)-methylpteroylglutamicacid 4-Amino-N(Sup10)-methylpteroylglutamic acid 4-amino-n(sup10)-methylpteroylglutamicacid 4-Amino-N10-methylpteroylglutamic acid 4-amino-n10-methylpteroylglutamicacid acide4-amino10-methylfolique Amethopterine a-methpterin CL-14377 EMT 25,299 emt25,299 Glutamic acid, N-(p-(((2,4-diamino-6-pteridinyl)methyl)methylamino)benzoyl)-
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