Nalidixic acid
Nalidixic acid
- CAS:
- 389-08-2
- MF:
- C12H12N2O3
- MW:
- 232.24
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Company Type
Properties
- Melting point:
- 227-229 °C (lit.)
- Boiling point:
- 374.4°C (rough estimate)
- Density
- 1.2243 (rough estimate)
- refractive index
- 1.6660 (estimate)
- storage temp.
- 2-8°C
- solubility
- chloroform: 20 mg/mL, clear
- pka
- pKa 6.11± 0.02(Approximate)
- form
- Powder
- color
- White to light yellow
- Water Solubility
- 0.1 G/L (23 ºC)
- Merck
- 14,6359
- BRN
- 750515
- Stability:
- Stable. Incompatible with strong oxidizing agents.
Safety Information
- Symbol(GHS)
GHS07,GHS08
- Signal word
- Warning
- Hazard statements
- H302-H351
- Precautionary statements
- P202-P264-P270-P280-P301+P312-P308+P313
- Hazard Codes
- Xn
- Risk Statements
- 63-42/43-40-20/21/22-22
- Safety Statements
- 22-36/37-45-24-36
- WGK Germany
- 2
- RTECS
- QN2885000
- F
- 8-10-23
- HS Code
- 29339190
- Toxicity
- LD50 in mice (mg/kg): 3300 orally; 500 s.c.; 176 i.v. (Lesher, 1962)
Use
1-Ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid (NegGram) occurs as a pale buff crystalline powder that is sparingly soluble in water and ether but solublein most polar organic solvents.Nalidixic acid is useful in the treatment of urinary tractinfections in which Gram-negative bacteria predominate.The activity against indole-positive Proteus spp. is particularlynoteworthy, and nalidixic acid and its congeners representimportant alternatives for the treatment of urinary tractinfections caused by strains of these bacteria resistant toother agents. Nalidixic acid is rapidly absorbed, extensivelymetabolized, and rapidly excreted after oral administration.The 7-hydroxymethyl metabolite is significantly more activethan the parent compound. Further metabolism of theactive metabolite to inactive glucuronide and 7-carboxylicacid metabolites also occurs. Nalidixic acid possesses at1/2elim of 6 to 7 hours. It is eliminated, in part, unchanged inthe urine and 80% as metabolites.
59 India supplier list of "Nalidixic acid"
- Product Name:Nalidixic acid
- Products Intro:Purity: 99% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: INDIA
- Product Name:Nalidixic acid
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: INDIA
- Product Name:Nalidixic acid
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg
- Company Type: Reagent
- Country/Region: INDIA
- Product Name:Nalidixic acid
- Products Intro:Purity: 99% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: INDIA
- Product Name:Nalidixic acid
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: INDIA
- Product Name:Nalidixic Acid IP/BP/EP/USP
- Products Intro:Purity: 99% | Package: 1 kg, 5 kg, 25 kg 100 kg, 1000 kg
- Company Type: Manufacturer
- Country/Region: INDIA
- Product Name:Nalidixicacid
- Products Intro:Brand:sigma aldrich | Product Number:N8878 | Purity:≥98%
- Company Type: Trader
- Country/Region: INDIA
- Product Name:Nalidixic acid 99% (HPLC)
- Products Intro:Brand：Glrinnovations | OriginalID：GLR19.071522
- Company Type: Trader
- Country/Region: INDIA
- Product Name:1-Ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridin-3-carbons?ure
- Company Type: Trader
- Country/Region: INDIA
- Product Name:Nalidixic acid
- Company Type: Reagent
- Country/Region: INDIA