N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine manufacturers and suppliers

N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine suppliers

N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine

CAS:: 315703-52-7

MF:: C19H18N4OS

MW:: 350.44

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Properties

storage temp.: Keep in dark place,Inert atmosphere,2-8°C

solubility: DMSO: ≥20mg/mL

form: powder

color: off-white to light brown

Safety Information

Symbol(GHS): GHS05,GHS07

Signal word: Danger

Hazard statements: H302-H318

Precautionary statements: P280-P305+P351+P338

Hazard Codes: Xn

Risk Statements: 22-41

Safety Statements: 26-36

WGK Germany: 3

Use

JK 184 is an imidazopyridine derivative that inhibits downstream hedgehog signaling, preventing Gli-dependent transcriptional activity (IC50 = 30 nM). It does so by inhibiting alcohol dehydrogenase 7 (IC50 = 210 nM) and depolymerizing microtubules, preventing their assembly, which is crucial for Gli function. JK 184 exhibits antiproliferative activity in a range of cancer cell lines (L3.6pl, Panc 05.04, BxPC3, D283 med, Daoy; GI50s = 3-21 nM) and in L3.6pl and BxPC3 pancreatic cancer xenograft models (0.2 mg/mouse/day).[Cayman Chemical]

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