4-Methylpyrazole suppliers
4-Methylpyrazole
- CAS:
- 7554-65-6
- MF:
- C4H6N2
- MW:
- 82.1
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Properties
- Melting point:
- 13°C
- Boiling point:
- 99-100 °C6 mm Hg(lit.)
- Density
- 0.993 g/mL at 25 °C(lit.)
- vapor pressure
- 7.136-87.85Pa at 20-50℃
- refractive index
- n
20/D 1.495(lit.)
- Flash point:
- 205 °F
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- soluble
- form
- Liquid After Melting
- pka
- 14.95±0.50(Predicted)
- Specific Gravity
- 0.993
- color
- Clear colorless to yellow
- Water Solubility
- soluble
- Sensitive
- Hygroscopic
- Merck
- 14,4226
- BRN
- 105204
- LogP
- 1.097 (est)
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Warning
- Hazard statements
- H302-H315-H319-H335
- Precautionary statements
- P261-P264-P270-P301+P312-P302+P352-P305+P351+P338
- Hazard Codes
- Xn
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26-36-24/25
- RIDADR
- 2810
- WGK Germany
- 3
- RTECS
- UQ7350000
- F
- 10-23
- HazardClass
- 6.1(b)
- PackingGroup
- III
- HS Code
- 29331990
- Toxicity
- LD50 (7 days) in mice, rats (mmol/kg): 3.8, 3.8 i.v.; 7.8, 6.5 orally (Magnusson)
Use
Fomepizole is the first drug indicated as an antidote for ethylene glycol poisoning (it has also shown promise as a treatment for methanol poisoning). Fomepizole is 4-methyl-1H-pyrazole active as a synthetic alcohol dehydrogenase inhibitor, blocking the formation of toxic ethylene glycol metabolites which are responsible for a severe metabolic acidosis and renal failure. In limited human studies, it reversed the toxicity of potentially lethal doses of ethylene glycol. The main urinary metabolite has been reported to be 4-carboxypyrazole by oxidation of the methyl group. Compared with the current treatment (ethanol), the duration of action is longer and the safety is improved, with no toxic effects reported.
238 supplier list of "4-Methylpyrazole"
$1.00/ 1kg
- Product Name:4-Methylpyrazole
- Products Intro:Purity: 99% | Package: 1kg;1USD
- Company Type: Reagent
- Country/Region: CHINA