Linsitinib suppliers
Linsitinib
- CAS:
- 867160-71-2
- MF:
- C26H23N5O
- MW:
- 421.49
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Company Type
Properties
- Melting point:
- >175°C (dec.)
- Density
- 1.39
- storage temp.
- -20°C
- solubility
- Soluble in DMSO (up to 30 mg/ml)
- form
- solid
- pka
- 14.84±0.40(Predicted)
- color
- Yellow
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Warning
Use
OSI-906 inhibits tumor growth in an IGF-1R-driven xenograft mouse model, with 100% TGI and 55% regression at a dose of 75 mg/kg and 60% TGI and no regression at a dose of 25 mg/kg. OSI-906 administration induces different elimination half-lives of itself in dog, rat and mice, the elimination half-lives are 1.18 hours, 2.64 hours and 2.14 hours, respectively. OSI-906 administration at different single dose once-daily in femal Sprague-Dawley rat and femal CD-1 mouse reveal that the Vmax is not dose-proportional to OSI-906 dose. OSI-906 elevates the blood glucose levels at a dose of 25 mg/kg after 12 days administration. OSI-906 administration at a single dose of 75 mg/kg in IGF-1R-driven full-length human IGF-1R (LISN) xenograft mouse model achieve maximal inhibition of IGF-1R phosphorylation (80%) between 4 and 24 hours with plasma drug concentrations of 26.6-4.77 μM. OSI-906 administered as a single dose of at 60 mg/kg in NCI-H292 xenografts mice inhibits uptake of glucose at 2, 4, and 24 hours post-treatment in vivo. OSI-906 inhibits the growth of tumors in NCI-H292 xenograft mouse model.
109 supplier list of "Linsitinib"
$6.68/ 1KG
- Product Name:Linsitinib
- Products Intro:Purity: 97%-99% | Package: 1KG;6.68USD
- Company Type: Trader
- Country/Region: CHINA
- Product Name:(1s,3s)-3-(8-Amino-1-(2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-3-yl)-1-methylcyclobutan-1-ol
- Products Intro:Purity: 96% | Package: 5G;10G;25G;50G;100G;250G;500G;1KG;389KG;
- Company Type: Manufacturer
- Country/Region: CHINA
$0.00-0.00 / 1KG
- Product Name:Linsitinib
- Products Intro:Purity: 98% | Package: 1KG;USD|10KG;USD|25KG;USD
- Company Type: Trader
- Country/Region: CHINA
- Main Products: Chemical Products,Daily chemical products,Specialty Chemical Products,synthetic material,food additives