Paclitaxel manufacturers and suppliers

Paclitaxel suppliers

Properties

Melting point:: 213 °C (dec.)(lit.)

Boiling point:: 774.66°C (rough estimate)

alpha: D20 -49° (methanol)

Density: 0.200

refractive index: -49 ° (C=1, MeOH)

Flash point:: 9℃

storage temp.: 2-8°C

solubility: methanol: 50 mg/mL, clear, colorless

form: powder

pka: 11.90±0.20(Predicted)

color: white

Water Solubility: 0.3mg/L(37 ºC)

λmax: 227nm(MeOH)(lit.)

Merck: 14,6982

BRN: 1420457

Stability:: Stable. Incompatible with strong oxidizing agents. Combustible.

InChIKey: RCINICONZNJXQF-MZXODVADSA-N

LogP: 3.950 (est)

CAS DataBase Reference: 33069-62-4(CAS DataBase Reference)

EPA Substance Registry System: Paclitaxel (33069-62-4)

Safety Information

Symbol(GHS): GHS05,GHS07,GHS08

Signal word: Danger

Hazard statements: H315-H317-H318-H334-H335-H340-H360D-H372

Precautionary statements: P202-P260-P280-P302+P352-P305+P351+P338-P308+P313

Hazard Codes: Xn

Risk Statements: 37/38-41-42/43-62-68-40-48-20/21/22-68/20/21/22

Safety Statements: 22-26-36/37/39-45

RIDADR: 1544

WGK Germany: 3

RTECS: DA8340700

F: 10-21

HazardClass: 6.1(b)

PackingGroup: III

HS Code: 29329990

Hazardous Substances Data: 33069-62-4(Hazardous Substances Data)

Toxicity: LD50 intraperitoneal in mouse: 128mg/kg

Use

Paclitaxel (commercial name, Taxol) a complex diterpene alkaloid isnaturally obtained from Taxus species (family Taxaceae). Paclitaxel has been provedas highly effective in the treatment of various types of cancers, since it acts as amicrotubule-stabilizing agent to protect against disassembly. Paclitaxel was developed by the National Cancer Institute, USA, as a drug for cancer therapy andused for the treatment of refractory ovarian cancer, metastatic breast and lung cancer,and Kaposi’s sarcoma (Srivastava et al. 2005). The natural source of paclitaxelis the bark of several Taxus species; however, the cost of extraction is very highsince the concentration of paclitaxel accumulation is very low (0.02% of dry weight)and also entails the destruction of natural resources (Cusido et al. 2014). Eventhough, paclitaxel can be chemically synthesized, but this process is not commerciallyviable. Plant cell cultures have been developed for the production of paclitaxelby Phyton Biotech in 1995, and in 2004 the FDA has approved the use of plantculture supply of paclitaxel/Taxol (Leone and Roberts 2013).

You can find Paclitaxel suppliers, manufacturers, and distributors from countries such as China, United States and the India here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.