Trimetazidine dihydrochloride suppliers
Trimetazidine dihydrochloride
- CAS:
- 13171-25-0
- MF:
- C14H24Cl2N2O3
- MW:
- 339.26
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Properties
- Melting point:
- 231-235 °C(lit.)
- storage temp.
- Refrigerator
- solubility
- Freely soluble in water, sparingly soluble in alcohol.
- form
- Solid
- color
- White to Off-White
- Merck
- 14,9705
- Stability:
- Hygroscopic
- InChIKey
- XIRALXKCBGTYSC-UHFFFAOYSA-N
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Warning
- Hazard statements
- H302-H315-H319-H335
- Precautionary statements
- P261-P264-P270-P301+P312-P302+P352-P305+P351+P338
- Hazard Codes
- Xn,Xi
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26-36
- WGK Germany
- 3
- RTECS
- TM2976100
- HazardClass
- IRRITANT
- HS Code
- 29339900
- Toxicity
- LD50 in male, female mice, rats (mg/kg): 91, 107, 124, 124 i.v.; 264, 245, 327, 288 i.p.; 528, 608, 1147, 987 orally (Harpey)
Use
Trimetazidine dihydrochloride is the dihydrochloride salt of Trimetazidine. It is a drug used for the treatment of angina pectoris. It is capable of improving the left ventricular function in diabetic patients suffering coronary heart disease as well as treating the symptoms of patients suffering heart failure of different etiologies. It takes effects through acting as an anti- ischemic metabolic agent being capable of improving the utilization efficiency of myocardial glucose by inhibiting the metabolism of fatty acid (through inhibiting the activity of mitochondrial long- chain 3-ketoacyl coenzyme A Thiolase). The shift from fatty acid oxidation to glucose oxidation optimizes cellular energy process in cells exposed to hypoxia or ischaemia, further maintaining the intracellular ATP levels and ensuring the normal function of ionic pumps and transmembrane sodium-potassium flow to maintain cellular homeostasis.
260 supplier list of "Trimetazidine dihydrochloride "
$7.00/ 1kg
- Product Name: Trimetazidine dihydrochloride
- Products Intro:Purity: 99% | Package: 1kg;7USD
- Company Type: Reagent
- Country/Region: CHINA