VX 702 manufacturers and suppliers

VX 702 suppliers

Properties

Boiling point:: 555.2±60.0 °C(Predicted)

Density: 1.503

storage temp.: -20°C

solubility: Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 2 mg/ml)

form: solid

pka: 10.65±0.50(Predicted)

color: White

Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

CAS DataBase Reference: 745833-23-2

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H315-H319

Precautionary statements: P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

HS Code: 2933399990

Use

VX-702 is a third generation inhibitor of p38 mitogen-activated protein (MAP) kinases, binding to both p38α and p38β (Kd = 3.7 and 17 nM, respectively) in an ATP-competitive fashion. It inhibits IL-6, IL-1β, and TNF-α production in LPS-primed blood with IC50 values of 59, 122, and 99 ng/ml, respectively. VX-702, at 1 μM, inhibits activation of p38 in platelets by thrombin, U-46619 , or collagen but does not block platelet aggregation in response to collagen. Although orally active, VX-702 provides only transient suppression of biomarkers of inflammation in ongoing rheumatoid arthritis.[Cayman Chemical]

You can find VX 702 suppliers, manufacturers, and distributors from countries such as CHINA, United States and the United Kingdom here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.