A77 1726 suppliers
A77 1726
- CAS:
- 163451-81-8
- MF:
- C12H9F3N2O2
- MW:
- 270.21
Suppliers by country/region
Company Type
Properties
- Melting point:
- 229-232°C
- Boiling point:
- 410.8±45.0 °C(Predicted)
- Density
- 1.424±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- DMSO: soluble5mg/mL, clear (warmed)
- pka
- 5.20±0.50(Predicted)
- form
- powder
- color
- white to beige
- λmax
- 203nm(MeOH)(lit.)
- Merck
- 14,9165
- Stability:
- Hygroscopic
- InChIKey
- UTNUDOFZCWSZMS-YFHOEESVSA-N
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Warning
- Hazard statements
- H225-H302+H312+H332-H319
- Precautionary statements
- P210-P280-P301+P312-P303+P361+P353-P304+P340+P312-P305+P351+P338
- Hazard Codes
- Xn
- Risk Statements
- 22
- WGK Germany
- 3
- HS Code
- 2926.90.4801
Use
A-771726 is the active metabolite of leflunomide, a prodrug approved by the FDA for treatment of rheumatoid arthritis. A-771726 reversibly inhibits dihydroorotate dehydrogenase, the rate-limiting step in the de novo synthesis of pyrimidines. It prevents activated lymphocytes from accumulating sufficient pyrimidines to support DNA synthesis (IC50s = 0.09, 3.5, and 12.5 μM for rat, mouse, and human, respectively). At higher doses, A-771726 inhibits tyrosine kinases responsible for early T cell and B cell signaling in the G0/G1 phase of the cell cycle. A-771726 has also been shown to inhibit the production of prostaglandin E2 in synoviocytes activated by TNF-α and IL-1α (IC50s = 7 and 3 μM, respectively) as well as inhibit MMP-1 and IL-6 production at concentrations >10 μM.[Cayman Chemical]
151 supplier list of "A77 1726"
- Product Name:Teriflunomide;A77 1726
- Products Intro:Purity: 98%+|Package: 1g;285USD|10g;0USD|100g;0USD|1000g;0USD
- Company Type: Trader
- Country/Region: CHINA
- Main Products: SARMS,isrib,nootropic,natural compounds,peptides
- Product Name:Teriflunomide
- Products Intro:Purity: 98%min | Package: 1Kg/Bag;USD|25Kg/Drum;USD
- Company Type: Trader
- Country/Region: CHINA
- Main Products: Linoleic Acid,Vitamin B12,Riboflavin,β-Nicotinamide Mononucleotide,Amoxicillin trihydrate