ABT 737 suppliers
ABT 737
- CAS:
- 852808-04-9
- MF:
- C42H45ClN6O5S2
- MW:
- 813.43
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Properties
- Melting point:
- 152-154°C
- Density
- 1.38±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Store in freezer, under -20°C
- solubility
- DMSO (Slightly), Methanol (Slightly, Heated, Sonicated)
- form
- Yellow solid
- pka
- 4.65±0.10(Predicted)
- color
- Light Yellow to Yellow
Safety Information
Use
ABT-737 is a small-molecule inhibitor of the anti-apoptotic proteins Bcl-2, Bcl-X(L) and Bcl-w, with potential pro-apoptotic and antineoplastic activities, with an affinity two to three orders of magnitude more potent than previously reported compounds. Mechanistic studies reveal that ABT-737 does not directly initiate the apoptotic process, but enhances the effects of death signals, displaying synergistic cytotoxicity with chemotherapeutics and radiation. ABT-737 exhibits single-agent-mechanism-based killing of cells from lymphoma and small-cell lung carcinoma lines, as well as primary patient-derived cells, and in animal models, ABT-737 improves survival, causes regression of established tumors, and produces cures in a high percentage of the mice.
108 supplier list of "ABT 737"