AEE788 suppliers
AEE788
- CAS:
- 497839-62-0
- MF:
- C27H32N6
- MW:
- 440.58
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Properties
- storage temp.
- -20°C
- solubility
- ≥22.05 mg/mL in DMSO; insoluble in H2O; ≥14.4 mg/mL in EtOH with ultrasonic
- form
- powder
- color
- white to beige
Safety Information
- RTECS
- UY8836200
Use
AEE788 is an inhibitor of both epidermal growth factor (EGF) and vascular endothelial growth factor (VEGF) receptor tyrosine kinase family members. It can inhibit EGFR and VEGFR tyrosine kinases with IC50 values of 2, 6, 77, and 59 nM for EGFR, ErbB2, KDR, and FLT1, respectively. AEE788 demonstrates antiproliferative activity against a range of EGFR and ErbB2-overexpressing cell lines and can inhibit the proliferation of EGF- and VEGF-stimulated human umbilical vein endothelial cells. It also has been shown to have antitumor and anti-angiogenic activity in numerous animal models of cancer.[Cayman Chemical]
86 supplier list of "AEE788"
$3.00/ 1KG
- Product Name:AEE788
- Products Intro:Purity: 98% | Package: 1KG;3USD
- Company Type: Trader
- Country/Region: CHINA
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