AG 490 suppliers
AG 490
- CAS:
- 134036-52-5
- MF:
- C17H14N2O3
- MW:
- 294.3
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Properties
- Melting point:
- 215
- Boiling point:
- 615.2±55.0 °C(Predicted)
- Density
- 1.337±0.06 g/cm3(Predicted)
- storage temp.
- −20°C
- solubility
- ethanol: 5 mg/mL
- pka
- 8.82±0.35(Predicted)
- form
- solid
- color
- yellow
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Warning
- Hazard statements
- H315-H319-H335
- Precautionary statements
- P261-P280a-P304+P340-P305+P351+P338-P405-P501a
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38-50-25
- Safety Statements
- 26-36-61-45
- WGK Germany
- 1
- Hazard Note
- Irritant/Keep Cold under -20C
- HS Code
- 2926907090
Use
A potent and specific inhibitor of the Jak-2 tyrosine kinase. In acute lymphoblastic leukemia (ALL) cells which abundantly express JAK-2, AG-490 dose-dependently inhibited DNA synthesis, blocked cell growth and induced apoptosis. AG-490 does not significantly inhibit other kinases such as Lck, Lyn, Btk, Syk and Src. AG-490 is cell permeable and is active in vivo.
143 supplier list of "AG 490"
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