Anagliptin manufacturers and suppliers

Anagliptin suppliers

Anagliptin

CAS:: 739366-20-2

MF:: C19H25N7O2

MW:: 383.45

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Properties

Melting point:: 115 - 119°C

Density: 1.33±0.1 g/cm3(Predicted)

storage temp.: Refrigerator

solubility: Chloroform (Slightly), Dichloromethane (Slightly), DMSO (Slightly)

form: Solid

pka: 12.40±0.46(Predicted)

color: White to Off-White

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H302

Precautionary statements: P280-P305+P351+P338

Use

Anagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor that was approved in Japan in November 2012 for the treatment of patients with Type 2 diabetes mellitus (T2DM). Anagliptin (also known asSK-0403) is a treatment for diabetes based on inhibition of DPP-4, an enzyme that is responsible for degradation of glucagon-like peptide 1 (GLP-1), a 30-amino acid peptide that is secreted in response to food intake. GLP-1 stimulates insulin secretion and inhibits glucagon secretion, which leads to lower levels of plasma glucose. Following the introduction of the first DPP-4 inhibitor, sitagliptin, in 2006, several members of the gliptin class have been approved worldwide. Anagliptin was discovered from an effort to replace a metabolically labile isoindoline group from an earlier DPP-4 inhibitor series with a stable bioisostere. Anagliptin is a potent DPP-4 inhibitor, with an IC50=3.8 nM and >10,000-fold selectivity over inhibition of DPP-8 and DPP-9.

You can find Anagliptin suppliers, manufacturers, and distributors from countries such as China, United States and the India here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.