AST 487 manufacturers and suppliers

AST 487 suppliers

AST 487

CAS:: 630124-46-8

MF:: C26H30F3N7O2

MW:: 529.56

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Properties

Melting point:: 162-164°C

Boiling point:: 563.1±50.0 °C(Predicted)

Density: 1.341±0.06 g/cm3(Predicted)

storage temp.: under inert gas (nitrogen or Argon) at 2-8°C

solubility: DMSO (Slightly), Methanol (Slightly)

pka: 13.33±0.70(Predicted)

form: Solid

color: White to Light Yellow

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H302-H315-H319-H335

Precautionary statements: P261-P305+P351+P338

Use

AST-487 is an inhibitor of RET (IC50 = 0.88 μM), FLT3 (Ki = 0.52 μM), KDR (IC50 = 0.17 μM), c-Abl (IC50 = 0.02 μM), and c-Kit (IC50 = 0.5 μM). It has been shown to inhibit RET autophosphorylation and activation of downstream effectors and to prevent the growth of human thyroid cancer cell lines with activating mutations of RET but not of lines without RET mutations. In xenografts of NIH3T3 cells expressing oncogenic RET and of the MTC cell line TT in nude mice, AST-487 dose dependently inhibited tumor growth. It also demonstrates antiproliferative effects on primary cells from acute myelocytic leukemia patients and on cell lines expressing FLT3-ITD or FLT3 kinase domain point mutants.[Cayman Chemical]

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